Results 71 to 80 of about 15,725 (313)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Object Detection and Image Segmentation with Deep Learning on Earth Observation Data: A Review—Part II: Applications

Remote Sensing, 2020
In Earth observation (EO), large-scale land-surface dynamics are traditionally analyzed by investigating aggregated classes. The increase in data with a very high spatial resolution enables investigations on a fine-grained feature level which can help us
Thorsten Hoeser, Felix Bachofer, Claudia Kuenzer   +2 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Challenges in Identifying Artificial Objects in the Near-Earth Object Population: Spectral Characterization of 2020 SO

The Planetary Science Journal
Since the dawn of the Space Age, hundreds of payloads have been launched into heliocentric space. As near-Earth object (NEO) surveys search deeper for small asteroids, more artificial objects in heliocentric orbits are being discovered.
Adam Battle, Vishnu Reddy, Juan A. Sanchez, Benjamin Sharkey, Tanner Campbell, Paul Chodas, Al Conrad, Daniel P. Engelhart, James Frith, Roberto Furfaro, Davide Farnocchia, Olga Kuhn, Neil Pearson, Barry Rothberg, Christian Veillet, Richard Wainscoat   +15 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Surface Heterogeneity, Physical, and Shape Model of Near-Earth Asteroid (52768) 1998 OR2

The Planetary Science Journal
On 2020 April 29, the near-Earth object (52768) 1998 OR2 experienced a close approach to Earth at a distance of 16.4 lunar distances (LD). 1998 OR2 is a potentially hazardous asteroid of absolute magnitude H = 16.04 that can currently come as close to ...
Maxime Devogèle, Anna McGilvray, Eric MacLennan, Courteney Monchinski, Sean E. Marshall, Dylan Hickson, Anne Virkki, Jon D. Giorgini, Lyu Abe, David Augustin, Amadeo Aznar-Macías, Philippe Baudouin, Raoul Behrend, Philippe Bendjoya, Zouhair Benkhaldoun, Josep Bosch, Alberto Cellino, Joseph Chatelain, Marc Deldem, Marin Ferrais, Rui Goncalves, Gerard Houdin, Marek Husárik, Emmanuel Jehin, Teddy Kareta, Myung-Jin Kim, Javier Licandro, Tim Lister, Hissa Medeiros, Petr Pravec, Jean-Pierre Rivet, Gerald Rousseau, Dong-Goo Roh, Brian Skiff, Patrick A. Taylor, Flaviane Venditti, David Vernet, Jean-Michel Vienney, Hong-Suh Yim, Luisa Zambrano-Marin   +39 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Visual-band Brightnesses of Near-Earth Objects that will be Discovered in the Infrared by NEO Surveyor

The Planetary Science Journal
Near-Earth Object (NEO) Surveyor will detect asteroids and comets using mid-infrared thermal emission, however ground-based followup resources will require knowledge of the expected visible light brightness in order to plan characterization observations.
Joseph R. Masiero, Tyler Linder, Amy Mainzer, Dar W. Dahlen, Yuna G. Kwon   +4 more
doaj   +1 more source

<italic>A History of Near-Earth Objects Research</italic>, by Erik M. Conway, Donald K. Yeomans, and Meg Rosenburg. [PDF]

, 2023
Steven J. Dick
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source