Results 201 to 210 of about 14,652 (268)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Seasickness, Sea Legs, and Gravity: Suppression of Motion Sickness, Development of Sea Legs, The Role of the Striated Organelle in the Vestibular Efferent System. [PDF]

Audiol Res
Longridge NS, Mallinson AI.
europepmc   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Assessment of geophysical methods for burial characterization: the old city cemetery in Murfreesboro, TN. [PDF]

Sci Rep
Alam MI, Doll WE, Bartel L, Sandoval V.
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Superheating in mafic magmas controls clinopyroxene nucleation delay and magma ascent dynamics. [PDF]

Nat Commun
Bonechi B, Arzilli F, Polacci M, Fabbrizio A, La Spina G, Michailidou E, Biagioli E, Brooker RA, Hazemann JL, Atwood RC, Di Genova D, Abeykoon S, Neave DA, Almeev RR, Burton M.   +14 more
europepmc   +1 more source

Abundant microchondrules in 162173 Ryugu suggest a turbulent origin for primitive asteroids. [PDF]

Nat Commun
Genge MJ, Almeida NV, van Ginneken M, Pinault L, Salge T, Wozniakiewicz PJ, Yano H, Desch SJ.   +7 more
europepmc   +1 more source

Lunar origin of Earth quasi-satellite Kamo'oalewa. [PDF]

Innovation (Camb)
Zhu MH, Morbidelli A, Wei Z, Ma P, Ding M, Luo XZ, Zhang H, Xu L, Zhuang Y, Cui XL.   +9 more
europepmc   +1 more source

MXtalTools: A Toolkit for Machine Learning on Molecular Crystals. [PDF]

J Chem Inf Model
Kilgour M, Tuckerman ME, Rogal J.
europepmc   +1 more source

A framework for evaluating predicted sperm trajectories in crowded microscopy videos. [PDF]

PLoS Comput Biol
Hart D, Cashwell K, Bhandari A, Premasinghe J, Schmidt C.   +4 more
europepmc   +1 more source