Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Rapid measurement of soluble xylo-oligomers using near-infrared spectroscopy (NIRS) and multivariate statistics: calibration model development and practical approaches to model optimization. [PDF]
Biotechnol Biofuels BioprodTillman Z, Gray K, Wolfrum E.
europepmc +1 more source
Advanced Science, EarlyView.Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao +9 more
wiley +1 more source
Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review. [PDF]
J Mother ChildAgudelo-Pérez S +6 more
europepmc +1 more source
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
Comparison of near infrared spectroscopy (NIRS) and near-infrared transillumination-backscattering sounding (NIR-T/BSS) methods. [PDF]
Sci Rep, 2020 Gruszecka A +12 more
europepmc +1 more source
Autonomous Solar Metallurgy for High‐Purity Gold Recovery from Electronic Waste
Advanced Science, EarlyView.Inspired by microbial strategies for metal uptake and biomineralization, defect‐rich copper sulfide (Cu31S16) functions as a solar metallurgical platform that unifies Au(III) capture, reduction, and self‐separation. The bioinspired design enables ultrafast gold recovery from electronic‐waste leachates and the spontaneous formation of millimeter‐scale ...
Chaopeng Liu +7 more
wiley +1 more source
Advanced Science, EarlyView.A novel bias‐programmable shortwave infrared (SWIR) vision sensor is developed using multi‐junction colloidal quantum dots (QDs). Under varying applied voltage, the back‐to‐back rectifying junctions effectively tune trapping centers to switch the device between high‐speed photodetector and persistent synapse modes.
Zhuoyang He +6 more
wiley +1 more source
Near-infrared spectroscopy (NIRS) <i>in vivo</i> assessment of skeletal muscle oxidative capacity: a comparison of results from short <i>versus</i> long exercise protocols and reproducibility in non-athletic adults. [PDF]
Front PhysiolTandirerung FJ +4 more
europepmc +1 more source
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source