Results 131 to 140 of about 244,175 (304)

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Overfishing and climate change elevate extinction risk of endemic sharks and rays in the southwest Indian Ocean hotspot.

PLoS ONE
Here, we summarise the extinction risk of the sharks and rays endemic to coastal, shelf, and slope waters of the southwest Indian Ocean and adjacent waters (SWIO+, Namibia to Kenya, including SWIO islands).
Riley A Pollom, Jessica Cheok, Nathan Pacoureau, Katie S Gledhill, Peter M Kyne, David A Ebert, Rima W Jabado, Katelyn B Herman, Rhett H Bennett, Charlene da Silva, Stela Fernando, Baraka Kuguru, Robin W Leslie, Meaghen E McCord, Melita Samoilys, Henning Winker, Sean T Fennessy, Caroline M Pollock, Cassandra L Rigby, Nicholas K Dulvy   +19 more
doaj   +1 more source

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders

Advanced Science, EarlyView.
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
wiley   +1 more source

An Integrated Approach to Determining the Risk of Overexploitation for Data-Poor Pelagic Atlantic Sharks [PDF]

, 2008
Assesses the risk of over-exploitation of sharks in Atlantic longline fisheries using three metrics based on multivariate statistics as a way to make management recommendations for species with limited data.

core  

Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics

Advanced Science, EarlyView.
Integrated computational‐biological programming enables secure in vivo data storage by generating code tables from either genomes or gene regulatory networks, expanding the encryption key space by over 100 orders of magnitude. Storing code tables within synthetic genes, genomes, or gene regulatory networks adds an additional layer of security by ...
Jiaxin Xu, Yu Wang, Haibo Zhou, Mingen Li, Yang Wang, Lingwei Wang, Hui Mei, Junbiao Dai, Shanze Chen, Xiaoluo Huang   +9 more
wiley   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

The complete chloroplast genome sequence and phylogenetic analysis of Juniperus coxii, a Near Threatened species

Juniperus coxii A. B. Jacks is a near threatened species on the IUCN Red List of Threatened Species. In this study, we reported the complete chloroplast genomes of J. coxii, which was 127,588 bp in length, with a GC content of 35.1%. A total of 122 genes were annotated, including 82 protein-coding genes, 36 tRNAs, and 4 rRNAs, and no inverse repeats ...
Wu, Junyao, Zheng, Chenling, Zhou, Fuqin, Li, Rui, Huang, Yuan   +4 more
openaire   +1 more source

The "Carex" fen vegetation of northern New South Wales [PDF]

, 2009
The floristic composition and extent of Carex-dominated fens in the New South Wales New England Tablelands Bioregion and Barrington Tops area (lat 28° 41’ S–31° 55’ S; long 151° 23’ E–152° 05’ E) together with outliers from the central west ...
Bell, Dorothy, Hunter, John T.
core  

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Integrative taxonomy of near-threatened species Pseudambassis lala (Hamilton 1822), an ornamental fish of the Gomti river, Uttar Pradesh, India

The Indian Journal of Animal Sciences
In the present study, Pseudambassis lala (Hamilton, 1822) was identified from Gomti River, Lucknow, Uttar Pradesh through morphological data (Classical Taxonomy) and molecular data (DNA Barcoding). This taxon is listed under the Near Threatened (NT) category of the IUCN Red List, 2024, and belongs to the Ambassidae family.
ASHISH SAHU, MAHENDER SINGH, T T AJITH KUMAR, UTTAM KUMAR SARKAR   +3 more
openaire   +2 more sources