Results 191 to 200 of about 463,878 (344)

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Chromatic‐Zone Mapping for Rapid Discovery of Antibacterial Alloys with Nanostructured Surfaces

Advanced Science, EarlyView.
A high‐throughput parallel chromatic‐zone screening strategy that enables the simultaneous screening of alloy composition and surface structure. Ultimately linking surface color, composition, and morphology with antimicrobial performance enables the screening and prediction of color zones, thereby reducing characterization requirements by 90% and ...
Qiu‐Yu Zhao, Yu‐Ying Liu, Li‐Wei Hu, Hong‐Xi Duan, Ming‐Xing Li, Yan‐Hui Liu, Jing Jiang, Zhen Lu, Wei‐Hua Wang   +8 more
wiley   +1 more source

Electrosensitive Heterogeneous Short Fibers via Acousto‐Electric Coupling for Sequential Bone Regeneration in Infectious Defects

Advanced Science, EarlyView.
Electrosensitive heterogeneous short fibers can accurately respond to ultrasonic field regulation through the synergistic interaction of piezoelectric and conductive dual elements. At an ultrasound intensity of 1.5 W cm−2, it can effectively activate bacterial peroxisome and necrotic apoptotic pathway and promote bacterial apoptosis.
Xiaoyu Han, Fan Wang, Pengcheng Xiao, Zheng Yang, Mingyue Liu, Zeyu Han, Zijie Wang, Anan Jiang, Jindong Tan, Juan Wang, Wenguo Cui, Dingqun Bai   +11 more
wiley   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Chromosome-level genome assembly and population genetic analysis of a near-threatened rosewood species (Dalbergia cultrata Pierre Graham ex Benth) provide insights into its evolutionary and cold stress responses

, 2023
Ping Huang, Changhong Li, Furong Lin, Yu Liu, Yichen Zong, Bin Li, Yongqi Zheng   +6 more
openalex   +1 more source

Nanoconfinement‐Steered Molecular Preorganization Enables Efficient Monoethanolamine Degradation through Electronically Modulated High‐Valent Iron–Oxo Pathways

Advanced Science, EarlyView.
Precise modulation of reaction pathways remains an unresolved challenge in peroxymonosulfate‐activated advanced oxidation processes. The spatial preorganization strategy in engineered confinement architecture enables regioselective bond cleavage in monoethanolamine via synergistic proton–electron transfer, redirecting its degradation from nonselective ...
Lin Zhang, Qin Dai, Xinyue Chen, Hang Yuan, Lei Xing, Zhimo Fang, Xiuze Li, Xiangke Wang, Lihui Zhang, Junping Zhao, Qiangwei Li, Lidong Wang   +11 more
wiley   +1 more source

Ultra‐Stable Topological Telluride Monolayers for Next‐Generation Battery Anodes and Sulfur Hosts

Advanced Science, EarlyView.
This study computationally designs 2D ternary metal tellurides (HfTiTe4, ZrTiTe4, and HfZrTe4) with unique electronic environments for battery applications. These materials offer low ion diffusion barriers, ultrahigh theoretical capacities, and robust ion binding, making them promising anodes.
Shehzad Ahmed, Awais Ghani, Rashid Mehmood, Ahsan Ali, Naveed Hussain, Abdul Khaliq, Jun Han, Kemeng Ji, Danish Khan, Imran Muhammad   +9 more
wiley   +1 more source

Food and habitat selection of Lepus brachyurus lyoni Kishida, a near-threatened species on Sado Island, Japan

Food and habitat selection of Lepus brachyurus lyoni Kishida, a near-threatened species on Sado Island, Japan
We determined the environmental requirements for Lepus brachyurus lyoni on Sado Island, Japan. during the winter when food resources are low Flare track survey sites were classified by vegetation type. The movement distances of hares, which indicated habitat preference, were evaluated as the relative length of tracks in a I-ha area In addition, we ...
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