Results 61 to 70 of about 4,109,239 (299)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Climatic changes and social transformations in the Near East and North Africa during the 'long 4th millennium BC: A comparative study of environmental and archaeological evidence

, 2016
This paper explores the possible links between rapid climate change (RCC) and social change in the Near East and surrounding regions (Anatolia, central Syria, southern Israel, Mesopotamia, Cyprus and eastern and central Sahara) during the ‘long’ 4th ...
J. Clarke, N. Brooks, E. Banning, M. Bar-Matthews, S. Campbell, Lee Clare, M. Cremaschi, S. Lernia, N. Drake, M. Gallinaro, S. Manning, K. Nicoll, G. Philip, Steve Rosen, Ulf-Dietrich Schoop, M. Tafuri, B. Weninger, A. Zerboni   +17 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mitogenomes from Egyptian Cattle Breeds: New Clues on the Origin of Haplogroup Q and the Early Spread of Bos taurus from the Near East

PLoS ONE, 2015
Background Genetic studies support the scenario that Bos taurus domestication occurred in the Near East during the Neolithic transition about 10 thousand years (ky) ago, with the likely exception of a minor secondary event in Italy.
Anna Olivieri, Francesca Gandini, A. Achilli, Alessandro Fichera, E. Rizzi, Silvia Bonfiglio, V. Battaglia, S. Brandini, A. De Gaetano, A. El-Beltagi, H. Lancioni, S. Agha, O. Semino, L. Ferretti, A. Torroni   +14 more
semanticscholar   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Impact of Macroeconomic Variables on Stock Returns: A Case of the Johannesburg Stock Exchange [PDF]

Revista Română de Statistică, 2018
The study assessed association of macroeconomic variables: inflation (INF), Money supply growth (M3), Interest rates (IR) and USD ZAR exchange rate (EX) using quarterly data from the year 1981Q1 to 2016 Q4 on stock price for the Johannesburg Stock ...
Boldwin Ndlovu , Faisal Faisal, Nil Gunsel Resatoglu, Turgut Türsoy   +3 more
doaj  

Impact Analysis on the Effective Synergy Between Climate Change, Ecological Degradation and Energy Consumption on Economic Growth in Nigeria

SAGE Open, 2021
There is growing global concern about the unpredictable nature of climate change and rapid ecological degradation, which has emanated from quest to enhance economic growth in many parts of the world.
Dahiru Alhaji-Bala Birnintsaba, Hüseyin Ozdeser, Andisheh Saliminezhad   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source