Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Simulation of millimeter wave dual differential probe response to standoff distance variation
Near-field microwave and millimeter wave nondestructive testing (NDT) techniques have been successfully used for detection of corrosion under paint.
Ghasr, Mohammad T. +4 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Pit size evaluation using millimeter wave nondestructive evaluation method
Corrosion precursor pitting size evaluation is a critical issue in the maintenance of aircrafts. Estimation of pit overall dimensions and especially its depth directly affects the required effort and cost associated with repair and maintenance of ...
Ghasr, Mohammad T. +4 more
core
Near field enhancements from angled surface defects : a comparison of scanning laser source and scanning laser detection techniques [PDF]
Enhancement of the Rayleigh wave signal amplitude at a surface defect, due to interference of incident, reflected and mode converted waves, has been reported by several authors, and it has been suggested that this could be used as a fingerprint of the ...
Edwards, R. S. (Rachel S.) +5 more
core +1 more source
Near-Field-Induced Ionization on Photo-Excited Gold Nanoparticles
Gold nanoparticles (AuNPs) have been widely utilized as an effective substrate for triggering molecular ionization upon photoexcitation. However, its underlying mechanism(s) remains unclear.
Keyuan Pu (14165603) +6 more
core +1 more source
Near-field Cosmology with the VLT [PDF]
5 pages, 3 figures, to appear in the proceedings of the ESO workshop "Science with the VLT in the ELT era", Springer Astrophysics and Space Science Proceedings, editor A ...
Mieske, Steffen, Jerjen, Helmut
openaire +2 more sources
IDENTIFIKASI STRUKTUR DASAR SMARANDACHE NEAR-RING
Penelitian ini membahas identifikasi struktur-struktur tersebut melalui definisi dan teorema dengan tahapan sebagai berikut : mengidentifikasi struktur ring dan perkembangannya seperti lapangan, near-ring dan near-field, mengidentifikasi struktur dasar ...
Yohana Y. Bakarbessy +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

