Results 151 to 160 of about 3,104,614 (297)

Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit. [PDF]

Drug Des Devel Ther
Al Zoubi R, Hadieh O, Alnabulsi S, Isawi IH, Liu S.   +4 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A Fiber Bragg Grating-Based Measurement Method for Outer-Ring Fault Detection in Rolling Bearings. [PDF]

Sensors (Basel)
Li H, Xu G, Gui X, Li Z.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A Large-Aperture Variable Iris Directly Driven by a V-Shaped Mode-Coupled Ultrasonic Motor: Design, Optimization, and Experimental Validation. [PDF]

Micromachines (Basel)
Lv B, Zhao J, Sun H, Bao X, Zhao T, Wang X, Yao Z, Li X, Li X.   +8 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Antichiral hinge states in a higher-order photonic nodal ring semimetal. [PDF]

Nat Commun
Peng Y, Mondal D, Yang Y, Wu W, Zhao B, Wei S, Liu Z, Qi W, Dai X, Cheng M, Li W, Zhang X, Li FF, Banerjee R, Wei M, Tian J, Zhou P, Mandal S, Zhang B, Liu GG.   +19 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

JWST stellar occultation reveals unexpected changes in Chariklo's ring system. [PDF]

Sci Adv
Santos-Sanz P, Gomes-Júnior AR, Morgado BE, Kilic Y, Kalup C, Kiss C, Pereira CL, Holler BJ, Morales N, Ortiz JL, Sicardy B, Rizos JL, Stansberry J, French RG, Hammel HB, Lin ZY, Souami D, Desmars J, Milam SN, Braga-Ribas F, Assafin M, Benedetti-Rossi G, Camargo JIB, Duffard R, Rommel FL, Fernández-Valenzuela E, Pinilla-Alonso N, Vara-Lubiano M.   +27 more
europepmc   +1 more source