Results 51 to 60 of about 1,375,879 (252)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Nonlinear Dynamical Friction in a Gaseous Medium

, 2009
Using high-resolution, two-dimensional hydrodynamic simulations, we investigate nonlinear gravitational responses of gas to, and the resulting drag force on, a very massive perturber M_p moving at velocity V_p through a uniform gaseous medium of ...
Bondi, Bondi, Butler, Conroy, Dokuchaev, Edgar, Escala, Escala, Foglizzo, Foglizzo, Fryxell, Furlanetto, Gradshteyn, Heberle, Hunt, Hunt, Hyosun Kim, Just, Kim, Kim, Kim, Kim, Koide, Liepmann, Matsuda, Matsuda, Milosavljević, Narayan, Ostriker, Ruffert, Ruffert, Ruffert, Schreier, Shankar, Shima, Sánchez-Salcedo, van Dyke, Woong-Tae Kim   +37 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

SiO masers in TX Cam: Simultaneous VLBA observations of two 43 GHz masers at four epochs

, 2004
We present the results of simultaneous high resolution observations of v=1 and v=2, J=1-0 SiO masers toward TX Cam at four epochs covering a stellar cycle.
Alcolea, Baudry, Benson, Benson, Boboltz, Boboltz, Bujarrabal, Bujarrabal, Cernicharo, Cho, Colomer, Cotton, Desmurs, Diamond, Diamond, Gray, Gray, Greenhill, Habing, Herpin, Hollis, Humphreys, Humphreys, J. E. Conway, Jiyune Yi, Kemball, Kwan, Lewis, Lockett, Miyoshi, Olofsson, P. J. Diamond, R. S. Booth, Walker, Yi   +34 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Matrix d.g. near-rings [PDF]

Proceedings of the Edinburgh Mathematical Society, 1998
Matrix near-rings had been defined by Meldrum and Van der Walt in 1986 and although a fair amount of results on the structure of these near-rings have been obtained since then, a satisfactory structure theory has yet to be developed for matrix d.g. near-rings.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Plasmonic interferometry: probing launching dipoles in scanning-probe plasmonics

, 2014
We develop a semi-analytical method for analyzing surface plasmon interferometry using near-field scanning optical sources. We compare our approach to Young double hole interferometry experiments using scanning tunneling microscope (STM) discussed in the
Aurélien Drezet, Cyriaque Genet, Guillaume Bachelier, Novotny L., Oriane Mollet, Serge Huant   +5 more
core   +3 more sources