Results 61 to 70 of about 1,375,879 (252)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A microstate for the 3-charge black ring

, 2006
We start with a 2-charge D1-D5 BPS geometry that has the shape of a ring; this geometry is regular everywhere. In the dual CFT there exists a perturbation that creates one unit of excitation for left movers, and thus adds one unit of momentum P.
Alday, Bak, Balasubramanian, Balasubramanian, Bena, Bena, Bena, Bena, Bena, Bena, Bena, Berglund, Cyrier, Dabholkar, Elvang, Elvang, Emparan, Gauntlett, Gauntlett, Giusto, Giusto, Giusto, Gutowski, Iizuka, Lunin, Lunin, Lunin, Lunin, Maldacena, Maldacena, Mathur, Mathur, Mathur, Mihailescu, Olsen, Samir D. Mathur, Stefano Giusto, Weinberg, Witten, Wu, Yogesh K. Srivastava   +40 more
core   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

MENGKONSTRUKSI DIRECT PRODUCT NEAR RING DAN SMARANDACHE NEAR RING

Journal of Fundamental Mathematics and Applications (JFMA), 2019
If we have two arbitrary non empty sets  ,then their cartesian product can be constructed. Cartesian products of two sets can be generalized into  number of  sets. It has been found that if the algebraic structure of groups and rings are seen as any set, then the phenomenon of cartesian products of  sets  can be extended to groups and rings.
Rizky Muhammad Bagas, Titi Udjiani SRRM, Harjito Harjito   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Near the horizon of 5D black rings

, 2009
For the five dimensional N=2 black rings, we study the supersymmetry enhancement and identify the global supergroup of the near horizon geometry. We show that the global part of the supergroup is OSp(4*|2)X U(1) which is similar to the small black string.
A. Castro, A. Castro, A. Castro, A. Dabholkar, A. Dabholkar, A. Sen, A. Sen, A. Strominger, A. Strominger, A. Van Proeyen, C.V. Johnson, D. Astefanesei, D. Astefanesei, D. Gaiotto, D. Gaiotto, D. Gaiotto, E. Bergshoeff, E. Bergshoeff, Farhang Loran, H. Elvang, H.K. Kunduri, Hesam Soltanpanahi, I. Bena, I. Bena, I. Bena, J.M. Lapan, J.M. Maldacena, J.P. Gauntlett, K. Goldstein, M. Alishahiha, M. Alishahiha, M. Alishahiha, M. Guica, N. Iizuka, P. Kraus, P. Kraus, R. Emparan, R.-G. Cai, T. Hartman, X.D. Arsiwalla   +39 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quantum oscillations of rectified dc voltage as a function of magnetic field in an "almost" symmetric superconducting ring

, 2007
Periodic quantum oscillations of a rectified dc voltage Vdc(B) vs the perpendicular magnetic field B were measured near the critical temperature Tc in a single superconducting aluminum almost symmetric ring (without specially created circular asymmetry ...
A. A. Firsov, I. Zapata, J.E. Mooij, S. V. Dubonos, S.V. Dubonos, V. I. Kuznetsov   +5 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evidence of the Galactic outer ring R1R2' from young open clusters and OB-associations

, 2016
The distribution of young open clusters in the Galactic plane within 3 kpc from the Sun suggests the existence of the outer ring R1R2' in the Galaxy.
Dambis, A. K., Glushkova, E. V., Melnik, A. M., Rautiainen, P.   +3 more
core   +1 more source