Results 91 to 100 of about 102,591 (310)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

One size doesn't fit all

, 2015
201
Niemi, Jarkko
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Deliverable D3.3 - Extended Transport System and Transparent Support of Non-NEAT Applications [Elektronisk resurs]

, 2017
This deliverable summarises and concludes our work in Work Package 3 (WP3) to extend the transport services provided by the NEAT System developed in Work Package 2, and to enable non-NEAT applications to harness the transport services offered by NEAT. We
Dreibholz, Thomas,, Rajiullah, Mohammad,, Fairhurst, Gorry,, Rozensztrauch, Tomasz,, Bozakov, Zdravko,, Ros, David,, Fosselie Hansen, Audun,, Brunström, Anna,, Hayes, David,, Tüxen, Michael,, Vyncke, Eric,, Isabel Sanchez Bueno, Maria, Rikter Evensen, Kristian,, Jones, Tom,, Grinnemo, Karl-Johan,, Hurtig, Per,   +15 more
core  

Decolorization of Rhodamine B dye by using multiwalled carbon nanotubes/Co–Ti oxides nanocomposite and Co–Ti oxides as photocatalysts

Applied Water Science, 2019
Functionalized multiwalled carbon nanotubes (F-MWCNTs)/Co–Ti oxide nanocomposites and neat Co–Ti oxide nanoparticles were synthesized by chemical reduction method.
Noor Zada, Khalid Saeed, Idrees Khan
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Won't you come to me in Canada? [music] /

, 1908
For voice and piano.; Cover title.; "By special arrangement with Francis, Day & Hunter ...".; "Sung by Miss Irene Beaumont".; "Mullen's popular 6d edition".; Also available online http://nla.gov.au/nla.mus-vn1912439; Library's N and NL copies lack ...
Neat, John.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source