ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source
In Silico Prioritisation of Similarity-Selected Small Molecules Targeting the IsdB NEAT Domain of <i>Staphylococcus aureus</i> as a Potential Antivirulence Strategy. [PDF]
Prommachote W +7 more
europepmc +1 more source
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source
Achieving Ultrastiff Polyampholyte Nanocomposite Hydrogels via the Synergistic Strategy of Effective Nanoparticle Aggregation and Multi-Bond Networks. [PDF]
Wang M, Long S, Li X, Huang Y.
europepmc +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Experimental and Computational Evaluation of Hybrid Bi<sub>2</sub>O<sub>3</sub>/WO<sub>3</sub> Nanoparticle-Filled Epoxy Composites for Lead-Free Tc-99m Gamma-Ray Shielding in Occupational Radiation Protection. [PDF]
Marshall SK +3 more
europepmc +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Quitline Counsellors' Experiences With Vaping and Nicotine Replacement Therapy for Smoking Cessation in Australian Drug and Alcohol Services. [PDF]
Rich JL +15 more
europepmc +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Enhancing Mechanical and Thermal Performance of Injection-Molded PLA via Nucleation and Processing Optimization. [PDF]
Gao P +6 more
europepmc +1 more source

