Results 41 to 50 of about 158,778 (309)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neck dissection does not add to morbidity or mortality of laryngectomy

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2019
Objectives: To examine the national rates of complications, readmission, reoperation, death and length of hospital stay after laryngectomy. To explore the risks of neck dissection with laryngectomy using outcomes.
Christopher C. Xiao, Sarah A. Imam, Shaun A. Nguyen, Marc P. Camilon, Andrew B. Baker, Terry A. Day, Eric J. Lentsch   +6 more
doaj   +1 more source

Functional radical cervical dissection for differentiated thyroid cancer: the experience of a single center [PDF]

, 2018
There is ongoing debate regarding the role of neck dissection in differentiated thyroid cancer, about its usefulness in elective settings, and the increased costs regarding morbidity and operative time.
Adrian, Tulin, Alecu, Lucian, Cristian, Balalau, Hainarosie, Razvan, Jecan, Radu, Nitipir, Cornelia, Orlov, Cristina, Pantea Stoian, Anca, Pituru, Silviu, Poiana, Catalina, Slavu, Iulian, Tomescu, Luminita, Tulin, Raluca   +12 more
core   +1 more source

[Neck dissection complications].

Brazilian journal of otorhinolaryngology, 2011
Because of the proximity of vital structures, certain complications are inherent to neck dissection (ND) for the treatment of patients with squamous cell carcinoma of the upper aerodigestive tract.To establish the incidence of complications of ND.A cross-sectional retrospective study of patient registries.
Dedivitis, Rogério Aparecido, Guimarães, André Vicente, Pfuetzenreiter, Elio Gilberto, de Castro, Mario Augusto Ferrari   +3 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Prognostic Effect of Neck Dissection and Risk Factors for Occult Lymph Node Metastasis in cN0 Parotid Carcinoma

Cancer Innovation
Objective This study aimed to explore the prognostic effect of neck dissection and to identify risk factors associated with occult lymph node metastasis (OLNM) in clinically node‐negative (cN0) parotid carcinoma (PC). Methods A retrospective analysis was
Yudong Ning, Yixuan Song, Yuqin He, Han Li, Shaoyan Liu   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tortuous Carotid Artery Extended to Neck Level IIb Mimicking the Metastatic Mass

Case Reports in Otolaryngology, 2016
Specifically in neck level IIb, the expected normal anatomy does not contain any vital structures and consequently it might direct a surgeon to perform rapid surgical dissection of tissues. Therefore aberrant anatomy of the vessels in the patients may be
Lokman Uzun, Oğuz Kadir Eğilmez, M. Tayyar Kalcioglu, Muhammet Tekin   +3 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Outcome of bimodality definitive chemoradiation does not differ from that of trimodality upfront neck dissection followed by adjuvant treatment for >6 cm lymph node (N3) head and neck cancer.

PLoS ONE, 2019
Currently, data regarding optimal treatment modality, response, and outcome specifically for N3 head and neck cancer are limited. This study aimed to compare the treatment outcomes between definitive chemoradiotherapy (CCRT) to the neck and upfront neck ...
Wan-Yu Chen, Tseng-Cheng Chen, Shih-Fan Lai, Tony Hsiang-Kuang Liang, Bing-Shen Huang, Chun-Wei Wang   +5 more
doaj   +1 more source