Results 71 to 80 of about 5,080,453 (387)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Study of intermediate velocity products in the Ar+Ni collisions between 52 and 95 A.MeV

, 1999
Intermediate velocity products in Ar+Ni collisions from 52 to 95 A.MeV are studied in an experiment performed at the GANIL facility with the 4$\pi$ multidetector INDRA.
A. Chbihi, A. Demeyer, A. Le Fèvre, A. Rahmani, A. Wieloch, A.D. N'Guyen, A.M. Maskay, Albergo, Angélique, B. Hurst, B. Tamain, Beaulieu, Bertsch, Borderie, Buta, C. Volant, Casini, Ch.O. Bacri, Chen, Chen, Colonna, Colonna, Cussol, D. Cussol, D. Doré, D. Durand, D. Gourio, D. Guinet, Danielewicz, Dayras, De La Mota, Dempsey, Doss, Durand, E. Galichet, E. Genouin-Duhamel, E. Gerlic, E. Plagnol, E. Rosato, E. Vient, Eudes, F. Bocage, F. Saint-Laurent, Fuchs, G. Auger, G. Politi, G. Tabacaru, Gosset, Gulminelli, Gustafsson, Gutbrod, Hauger, He, J. Colin, J. Péter, J.C. Steckmeyer, J.D. Frankland, J.F. Lecolley, J.L. Charvet, J.L. Laville, J.P. Wieleczko, Jacak, Krofcheck, Kwiatkowski, L. Nalpas, L. Tassan-Got, Lanzano, Larochelle, Lecolley, Lefort, Li, Lukasik, M. Assenard, M. Germain, M. Louvel, M. Parlog, M. Stern, Ma, Marie, Milkau, Montoya, Moretto, Moretto, N. Le Neindre, Natowitz, O. Lopez, O. Tirel, Ogilvie, Ono, P. Eudes, P. Lautesse, Pak, Peilert, Ph. Buchet, Pochodzalla, Popescu, Pouthas, Pouthas, Péter, Péter, Péter, R. Bougault, R. Brou, R. Dayras, R. Legrain, Rivet, S Goldhaber, S. Salou, Sauvestre, Scheid, Shen, Siwek, Sobotka, Steckmeyer, Stefanini, Stuttgé, Stöcker, Sullivan, T. Lefort, T. Reposeur, Tsang, Tõke, Westfall, Westfall, Wile, Xi, Xu, Y.G. Ma, Zhang   +128 more
core   +3 more sources

Branchial cleft cysts : a pictorial review [PDF]

, 2018
Cystic masses of the neck may represent a wide variety of pathological conditions. Among these, branchial anomalies are the commonest paediatric congenital lesions of the head and neck.

core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Identification of druggable binding sites and small molecules as modulators of TMC1

Communications Biology
Our ability to hear and maintain balance relies on the proper functioning of inner ear sensory hair cells, which translate mechanical stimuli into electrical signals via mechano-electrical transducer (MET) channels, composed of TMC1/2 proteins.
Pedro De-la-Torre, Claudia Martínez-García, Paul Gratias, Matthew Mun, Paula Santana, Nurunisa Akyuz, Wendy González, Artur A. Indzhykulian, David Ramírez   +8 more
doaj   +1 more source

Prenatal ultrasound diagnosis and prognosis assessment of fetal neck masses

Frontiers in Pediatrics
ObjectiveThis study retrospectively analyzed the prenatal ultrasound features and outcomes of fetal neck masses to improve the understanding of fetal neck masses and provide evidence for prenatal consultation, prognosis assessment, delivery mode ...
Peipei Zhang, Xining Wu, Yunshu Ouyang, Tianrui Yang, Yixiu Zhang, Hui You, Yan Lv, Yulin Jiang, Qing Dai, Hua Meng   +9 more
doaj   +1 more source

Intravenous Neck Injections in a Drug Abuser Resulting in Infection of a Laryngocele

Asian Journal of Surgery, 2005
A pyolaryngocele is an uncommon complication of a laryngocele that has become infected. We present a case of a pyolaryngocele that was probably due to repeated injections in the neck veins. The pathogenesis, clinical features and management are discussed
Jeevanan Jahendran, Gurdeep Singh Mann, Balachandran Appoo   +2 more
doaj   +1 more source

A rare cause requiring consideration in the differential diagnosis of neck masses: tularemia

Journal of Infection in Developing Countries, 2023
Introduction: Tularemia is a zoonotic disease caused by the Gram-negative coccobacillus Francisella tularensis. It is frequently overlooked in the differential diagnosis of neck masses because of its rarity.
Abdulkadir Sahin, Korhan Kilic, Muhammed Sedat Sakat, Bulent Aktan, Hazal Altunok, Fatma Kesmez Can   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source