Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
Compensatory "rolling-like" tongue motion after circumferential tongue necrosis without reconstruction: A functional adaptation phenomenon. [PDF]
Shudo A.
europepmc +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Diagnostic performance and reader confidence of MRI-derived CT-like images in patients with femoral head necrosis. [PDF]
Herr FL +12 more
europepmc +1 more source
Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents
Postoperative gastric leaks are often treated with off‐label biliary double‐pigtail stents, yet conventional extruded designs are not optimized for leak anatomy, can migrate, and may limit abscess evacuation. PETALS is introduced to optimize transmural drainage geometry and enable patient‐specific 3D‐printable stents.
Parima Phowarasoontorn +14 more
wiley +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Toward precision in diagnosing necrotic bowel: Gold standards and weighted risk stratification. [PDF]
Liu X, Liu P.
europepmc +1 more source
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu +10 more
wiley +1 more source
Pediatric Migraine Aura Status and Cortical Laminar Necrosis: A Clinical Case and a Narrative Review. [PDF]
Cernigliaro F +7 more
europepmc +1 more source

