Results 21 to 30 of about 1,608,164 (308)

Systemic Review for The Effectiveness of Current Conservative Treatment in Necrotizing Pancreatitis [PDF]

Kosin Medical Journal, 2014
The standard treatment of pancreatic necrosis has been surgical necrosectomy. There has been debate on whether early surgical intervention can reduced by infected pancreatic necrosis (IPN).
Jungik Park, Ungseok Yang
doaj   +1 more source

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

Journal of Experimental Medicine, 2019
Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated necrosis induced by accumulation of free iron and toxic lipid peroxides. We
Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam, N. Riteau, Olena Kamenyeva, Lara R Mittereder, K. Mayer-Barber, B. Andrade, A. Sher   +8 more
semanticscholar   +1 more source

Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors

FEBS Open Bio, 2017
Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis ...
Osamu Sano, Ken‐ichi Kazetani, Ryutaro Adachi, Osamu Kurasawa, Tomohiro Kawamoto, Hidehisa Iwata   +5 more
doaj   +1 more source

Cytotoxicity and Pro-Apoptotic Activity of 2,2´-Bis[4,5-bis(4-hydroxybenzyl)-2-(4-hydroxyphenyl)cyclopent-4-en-1,3-dione], a Phenolic Cyclopentenedione Isolated from the Cyanobacterium Strain Nostoc sp. str. Lukešová 27/97

Molecules, 2011
The cytotoxicity of the polyphenol 2,2´-bis[4,5-bis(4-hydroxybenzyl)-2-(4-hydroxyphenyl)cyclopent-4-en-1,3-dione], nostotrebin 6 (NOS-6), was tested under in vitro conditions using mouse fibroblasts (BALB/c cells).
Jan Vacek, Jan Hrbáč, Jiří Kopecký, Jitka Vostálová   +3 more
doaj   +1 more source

Grade I meningiomas with atypical characteristics: a worse prognosis

Arquivos de Neuro-Psiquiatria
The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients’ prognosis, while correlating the ...
Débora S. Marcos, Manoel A. Paiva Neto, Pedro Góes, Celina T. F. Oshima, Marcelo S. Silva, João N. Stávale   +5 more
doaj   +1 more source

Overview on the mechanisms of drug-induced liver cell death

Annals of Hepatology, 2002
Drug-induced hepatotoxicity is a significant and still unresolved clinical problem. The limitation in current knowledge regarding mechanisms of hepatic toxicity renders most of the preclinical review process failing and most of drug-induced hepatic ...
Ignazio Grattagliano, MD, Piero Portincasa, MD PhD, Vincenzo O Palmieri, MD PhD, Giuseppe Palasciano, MD PhD   +3 more
doaj   +1 more source

Antimicrobial Peptide Brevinin-1RL1 from Frog Skin Secretion Induces Apoptosis and Necrosis of Tumor Cells

Molecules, 2021
Cancer has always been one of the most common malignant diseases in the world. Therefore, there is an urgent need to find potent agents with selective antitumor activity against cancer cells.
Xiaoman Ju, Dongmei Fan, Lingmei Kong, Qihong Yang, Yiying Zhu, Shaohua Zhang, Guifeng Su, Yan Li   +7 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

A new protocol (THIS and FAT) for the treatment of filler-induced vascular occlusion: a case series

Frontiers in Medicine
IntroductionHyaluronic acid (HA) fillers are generally safe; however, the most significant complication is vascular occlusion. Several therapeutic protocols have been proposed for managing ischemia.
Shahriar Nazari, Nabil Fakih-Gomez, Nabil Fakih-Gomez, Nima Hadadian, Foroohe Bayat, Behnam Bohlouli, Cristina Muñoz-Gonzalez, Cristina Muñoz-Gonzalez, Mohammad Reza Pourani   +8 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source