Results 81 to 90 of about 345,328 (274)

Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury

Frontiers in Immunology
Cells die by necrosis due to excessive chemical or thermal stress, leading to plasma membrane rupture, release of intracellular components and severe inflammation. The clearance of necrotic cell debris is crucial for tissue recovery and injury resolution,
Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques   +5 more
doaj   +1 more source

Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]

, 2004
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Baumgartner, Reinhold, Bise, Karl, Frimberger, Dominic, Hofstetter, Alfons, Höppner, Michael, Knüchel, Ruth, Kriegmair, Martin, Lein, Michael, Reich, Oliver, Schneede, Peter, Sroka, Ronald, Stocker, Susanne, Zaak, Dirk   +12 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transgenic tobacco plants expressing the Potato virus X open reading frame 3 gene develop specific resistance and necrotic ring symptoms after infection with the homologous virus [PDF]

, 2001
Tobacco plants were transformed with the open reading frame 3 gene from Potato virus X (PVX) coding for the p12 protein. Although the transgenic plants exhibited a normal morphological aspect, microscopic examination revealed extensive alterations in ...
Cabral, Silvia, Calamante, Gabriela, Kobayashi, Ken, Maldonado, Sara Beatriz, Mentaberry, Alejandro Nestor   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influence of photobiomodulation therapy on root development of rat molars with open apex and pulp necrosis

Brazilian Oral Research
This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks.
Ivana Maria ZACCARA, Alexander Pompermayer JARDINE, Letícia Boldrin MESTIERI, Ramiro Martins QUINTANA, Luciano JESUS, Maria Stella MOREIRA, Fabiana Soares GRECCA, Manoela Domingues MARTINS, Patrícia Maria Poli KOPPER   +8 more
doaj   +1 more source

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice

Scientific Reports, 2017
Fungal peritonitis in a patient on peritoneal dialysis (PD) is a refractory injury accompanied by severe inflammation, predisposing patients to a poor prognosis.
Takako Tomita, Satoko Arai, Kento Kitada, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Daisuke Nakano, Emiri Hiramoto, Yoshifumi Takei, Shoichi Maruyama, Akira Nishiyama, Seiichi Matsuo, Toru Miyazaki, Yasuhiko Ito   +13 more
doaj   +1 more source

A case of histoplasmosis Report 1. Cinical, mycological and pathological observations [PDF]

, 1957
In our country it has been believed that there is no histoplasmosis here in Japan. However, from the above clinical signs, radiological characteristics, laboratory tests, pathological and mycological examinations, and experimental findings, we believe ...
Hamazaki, Yukio, Hitomi, Hiroshi, Maekawa, Seigen, Mimura, Koji, Ogawa, Katsuo, Uejima, Akira, Yamato, Hitoshi   +6 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Viruses infecting carnations and dianthus species in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science at Massey University [PDF]

, 1975
Five viruses were detected in commercial carnations and these and a further four occurred in Dianthus species from gardens. Carnation mottle virus (CarMV) and carnation etched ring virus (CERV-50) were widespread in commercial carnations; arabis mosaic ...
Bennett, Peter Roger
core