Results 41 to 50 of about 323,794 (349)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Real‐world drug survival of Brodalumab, in patients with psoriasis switched from Ixekizumab: Results of a single centre retrospective study (BroSwitch)

JEADV Clinical Practice, 2023
Background Biologicals are a widely used treatment for psoriasis (PsO), however, biologicals are expensive and while continuous use is warranted, sometimes need switching.
Jolijn C. Bethlem, Jenny A. H. M. Janssens, Milan Tjioe   +2 more
doaj   +1 more source

Boschcultuur in Nederland [PDF]

De Economist, 1880
n ...
openaire   +2 more sources

Arbeidspiek in beeld op biologische bedrijven [PDF]

, 2001
Arbeidsbegroting (arbeidsfilm in 13 perioden van vier weken), arbeidsbehoefte en arbeidsorganisatie (los of vast personeel) in de biologische akkerbouw- en vollegrondsgroenteteelt, voor bedrijfsopzetten (bouwplan) die representatief zijn voor vijf regio ...
Schoorlemmer, H.B., Stokkers, R.
core   +1 more source

A soil sampling program for the Netherlands [PDF]

, 2007
Soil data users in The Netherlands were inventoried for current and future data needs. Prioritized data needs were used to design the Netherlands Soil Sampling Program (NSSP) as a framework containing 3 groups of related projects: map upgrading, map ...
DE GRUIJTER, JJ, Finke, Peter, VISSCHERS, R   +2 more
core   +3 more sources

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Het Effect van Individuele en Groepsbehandeling voor Adolescenten met Borderlineproblematiek

Jeugd in Ontwikkeling
Beginnende borderlineproblematiek wordt bij adolescenten ondergediagnosticeerd en onderbehandeld, wat de kans op het ontwikkelen van een ‘full-blown’ persoonlijkheidsstoornis vergroot. Dit heeft ingrijpende gevolgen, zoals een verhoogd risico op suïcide,
Tessa van der Laan, Marlieke Wilms, Astrid Menninga   +2 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

It Takes a Village to Raise Professionals

Jeugd in Ontwikkeling
Bij complexe casuïstiek is structurele aandacht voor (gezamenlijk) professioneel leren op verschillende niveaus nodig, om de kwaliteit van zorg aan GMCP te waarborgen.
Els Evenboer, Marianne Welmers van de Poll, Margo te Roller   +2 more
doaj   +1 more source