Results 81 to 90 of about 323,794 (349)

The Defining Characteristics of the Buurtzorg Nederland Model of Home Care from the Perspective of Buurtzorg Nurses [PDF]

, 2016
In the summer of 2015, I spent nine weeks in the Netherlands conducting qualitative research on the Buurtzorg model, an award-winning home healthcare organization, whose name translates to “neighborhood care.” I focused my research on the Buurtzorg ...
White, Colleen
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Modelling Business Ownership in the Netherlands [PDF]

Beschrijving van een empirisch model ter verklaring van het aantal zelfstandige ondernemingen in Nederland. Een dergelijk model voorziet in het maken van scenario’s gemaakt voor de toekomstige ontwikkeling van het aantal ondernemingen in Nederland.
Gerrit de Wit, Niels Bosma, Sander Wennekers, Wim Zwinkels   +3 more
core  

Reframing the remake : Dutch-Flemish monolingual remakes and their theoretical and conceptual implications [PDF]

, 2016
In this article, we explicitly take distance from what we would call the ‘anti-remake debates’, or a normative standpoint towards remakes. We instead aim for a more nuanced reading of the remake practice.
Cuelenaere, Eduard, Joye, Stijn, Willems, Gertjan   +2 more
core   +2 more sources

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Evaluating cloudcare, a population health management system, in persons with type 1 diabetes: an observational study

BMC Endocrine Disorders
Background Innovations in diabetes technology have consistently improved outcomes of persons with type1 diabetes (PWDs). However, the volumes of data that these technologies yield require different workflows to alleviate healthcare professionals’ (HCPs ...
Cornelis A. J. van Beers, Sander Last, Pim Dekker, Erwin Birnie, Nico Riegman, Francisca van der Pluijm, Christine Fransman, Henk J. Veeze, Henk-Jan Aanstoot   +8 more
doaj   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

NCR-days 2008 : 10 years NCR: November 20-21 [PDF]

De verschillende subthema’s van de NCR-dagen 2008, (i) Stroomgebied en Overstromingsrisico management (ii) Hydrologie en (iii) Geomorfodynamica en Morfologie, dekken een groot gedeelte van het hedendaagse onderzoek dat in Nederland op rivierkundig gebied
Alterra - Centrum Landschap, Erdbrink, C.D., Os, A.G., van   +2 more
core   +1 more source

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

Redactioneel: Gezinnen met meervoudige en complexe problemen

Jeugd in Ontwikkeling
‘Gezinnen met meervoudige en complexe problemen’ is het eerste themanummer van Jeugd in Ontwikkeling. Waarom een themanummer? De ondersteuning van de gezinnen waarover dit themanummer gaat, vraagt om een integrale, domeinoverstijgende aanpak en nodige ...
Jana Knot-Dickscheit, Leonieke Boendermaker   +1 more
doaj   +1 more source