Results 191 to 200 of about 2,242,699 (263)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Supporting the Implementation and Addressing the Challenges of the EU HTA Regulation. [PDF]

open access: yesJ Mark Access Health Policy
Julian E   +15 more
europepmc   +1 more source

Difficult intravenous access (DIVA) in the adult population: an umbrella review. [PDF]

open access: yesBMJ Open
Torné-Ruiz A   +5 more
europepmc   +1 more source

From Complexity to Competency: International Nursing Perspectives on Comprehensive Geriatric Assessment. [PDF]

open access: yesGeriatrics (Basel)
Fradelos EC   +13 more
europepmc   +1 more source

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