Results 141 to 150 of about 192,419 (284)

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel   +6 more
wiley   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji   +7 more
wiley   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

open access: yesAdvanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim   +6 more
wiley   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

open access: yesAdvanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong   +12 more
wiley   +1 more source

Need for Closure and Cognitive Inhibition of Unwanted or Irrelevant Information

open access: yesProcedia - Social and Behavioral Sciences, 2014
AbstractNeed for closure is a construct that influences the way people perceive social world. Need for closure reflects a preference towards certainty and stability, clarity and firm rules, definitive answers to questions, and an aversion to ambiguity and lack of control. People with high scores at the need of closure dimension of personality are prone
openaire   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

open access: yesAdvanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode   +16 more
wiley   +1 more source

Recent Progress on Flexible Multimodal Sensors: Decoupling Strategies, Fabrication and Applications

open access: yesAdvanced Materials, EarlyView.
In this review, we establish a tripartite decoupling framework for flexible multimodal sensors, which elucidates the underlying principles of signal crosstalk and their solutions through material design, structural engineering, and AI algorithms. We also demonstrate its potential applications across environmental monitoring, health monitoring, human ...
Tao Wu   +10 more
wiley   +1 more source

Respiratory Signal Processing and Analysis Using Flexible Capacitive Sensor Data

open access: yesAdvanced Materials Technologies, EarlyView.
Capacitive pressure sensors based on poly(glycerol sebacate) (PGS) substrates are developed for continuous, non‐invasive respiratory monitoring. Integrated with a signal processing algorithm, they enable accurate tracking of thoracic expansion and retraction.
Bernardo A. Vicente   +3 more
wiley   +1 more source

Need for Cognitive Closure and Learning: Research Gaps and Future Directions

open access: yesSCT Proceedings in Interdisciplinary Insights and Innovations
Introduction: This review examined the interplay among need for cognitive closure, learning, emotions and prejudice. The need to explore this interplay arises from the lack of comprehensive studies addressing how need for cognitive closure affects information processing in broader contexts, especially in relation to important social issues (such as ...
Maximiliano Luis Leiva, Jazmin Cevazco
openaire   +1 more source

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