Results 121 to 130 of about 4,349,033 (348)
Justice and conservation: The need to incorporate recognition
, 2016 In light of the Aichi target to manage protected areas equitably by 2020, we ask how the conservation sector should be incorporating concerns for social justice.
Adrian Martin +6 more
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
We need to talk about Hearer's Meaning!
Journal of Pragmatics, 2023 M. Hansen, M. Terkourafi
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Personal meanings in the construction of need for total knee replacement surgery
Social Science & Medicine, 2006 This study explores patients' personal meanings of knee osteoarthritis (OA) and total knee replacement (TKR). Personal meanings are important because decisions regarding the need for TKR do not seem to be explained by symptoms alone. A total of 18 semi-structured interviews were conducted with a purposive sample of respondents who were listed for TKR ...
Toye, F, Barlow, J, Wright, C, Lamb, S
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Research in PsychotherapyIdentifying predictors of long-term therapy outcome is crucial in shaping effective therapy programs. This study examined sense of meaning in life, religiosity, and spirituality as potential predictors for long-term therapy success following psychiatric-
René Hefti +4 more
doaj +1 more source
, 2009 Since the passing of two high-profile state legislative bills aimed at Arizona\u27s Latino residents this past April, the significance of ethnicity for American citizens has once again surfaced as a topic for national debate.
Rojas, Maythee
core +1 more source
The Demand and Need for Transparency and Disclosure in Corporate Governance
, 2014 Transparency and disclosure (T&D) are essential elements of a robust corporate governance framework as they provide the base for informed decision making by shareholders, stakeholders and potential investors in relation to capital allocation, corporate ...
Benjamin W. W. Fung
semanticscholar +1 more source