Results 131 to 140 of about 4,349,033 (348)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Mapping a Blank Spot and Making Empty Spaces
JoLMAThis study explores the ontological assumptions of mapping as active processes, rather than passive representations and discusses the need for pragmatic guidelines in map-making, as maps only acquire meaning through their users’ minds and bodies.
Török, Zsolt
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Earth-Science Education: From all over the World to East-Timor [PDF]
, 2012 Earth Science education (ESE) emerges as a relatively new research area and there is an unquestioned need for improving students´ abilities on that field (American Geological Institute, 2008), taking into account that it is important for students ...
Andrade, António +3 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts
Frontiers in PsychologyIntroductionThis research integrates criminological and psychological literature by applying the 3N model of radicalization to predict criminal attitudes. Specifically, we conceptualize “need” as the search for meaning, “networks” as deviant associations,
Jocelyn J. Bélanger +7 more
doaj +1 more source
The unbearable trauma of being : death, hope, and (in)humanity in the work of Cormac McCarthy [PDF]
, 2016 For as long as the self-christened homo sapiens has roamed the Earth, various mythologies and their respective afterlives have followed without fail.
Dent, Kelly
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The meaning of net zero and how to get it right
Nature Climate Change, 2021 S. Fankhauser +14 more
semanticscholar +1 more source