Results 121 to 130 of about 3,850,072 (298)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

SYRINGE AND NEEDLE EXCHANGE PROGRAMS: A VALUABLE HARM REDUCTION TECHNIQUE IN THE BATTLE AGAINST INJECTION DRUG USE [PDF]

, 2012
In the last two decades there has been a growing interest surrounding the topic of clean needle exchange programs, the effects they have on injection drug users, their effectiveness in the prevention and spreading of HIV, AIDS and other blood borne ...
Woods, Stephanie M
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

History of injection drug use in the month preceding incarceration in Iranian prisons

Scientific Reports
This study aimed to investigate the prevalence and pattern of injecting drug use (IDU) in Iranian incarcerated people one month before their imprisonment.
Mitra Darbandi, Willi McFarland, Soheil Mehmandoost, Fatemeh Tavakoli, Maliheh Sadat Bazrafshan, Naser Nasiri, Ali Akbar Haghdoost, Meraj Sharifi, Roya Safari Faramani, Hamid Sharifi   +9 more
doaj   +1 more source

Harm Reduction: Public Health and Public Order [PDF]

, 2007
Reviews international literature on harm reduction programs and their impact on crime and public order, with a focus on medication-assisted treatment and needle exchange programs for drug ...

core  

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

PRO: Needle Exchange Programs Should Be Instituted to Reduce Hepatitis C Virus Transmission. [PDF]

Clin Liver Dis (Hoboken), 2018
Cotter TG, Stier MW, Aronsohn A.
europepmc   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

CON: Needle Exchange Programs Should Not Be Instituted to Reduce Hepatitis C Virus Transmission. [PDF]

Clin Liver Dis (Hoboken), 2018
O'Riordan K, Khan M, Mazulis A.
europepmc   +1 more source

Valuing users of Needle Syringe Exchange programs: Design approaches within the healthcare sector [PDF]

, 2017
Injecting drug users are among the most marginalised and stigmatised groups in society. This is a wicked problem exacerbated by multifaceted assumptions, misconceptions, and stereotypes surrounding injecting drug users.
Haddad, Hanadi, Pekaar, Samantha
core