Results 161 to 170 of about 4,823,352 (315)

The Importance of Content Validity in Accredited Continuing Medical Education/Continuing Professional Development (CME/CPD). [PDF]

J CME
Schaefer R, Regnier K, Smith M, Elsayed E, Parsa-Parsi R, Stein J, Kloiber O, Griebenow R.   +7 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development and Psychometric Evaluation of a Pulmonary Rehabilitation Information Needs Scale for Patients with Chronic Obstructive Pulmonary Disease. [PDF]

Int J Chron Obstruct Pulmon Dis
Tang Y, Zhao X, Huang Z, Kaminga AC, Li Z, Xiong Y, Liu Z, Huang Y, Yang G, Yi Q.   +9 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

COPD patients’ experiences, self-reported needs, and needs-driven strategies to cope with self-management

, 2019
Jonina Sigurgeirsdottir,1,2 Sigridur Halldorsdottir,3 Ragnheidur Harpa Arnardottir,3–5 Gunnar Gudmundsson,1,6 Eythor Hreinn Bjornsson21Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 2Reykjalundur Rehabilitation Center, Mosfellsbaer,
Gudmundsson G, Bjornsson EH, Sigurgeirsdottir J, Halldorsdottir S, Arnardottir RH   +4 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Additional support needs and approaches to dispute resolution: the perspectives of Scottish parents

, 2009
This paper draws on data from an ESRC funded project (RES-062-23-0803) which explores the use of dispute resolution mechanisms in the field of special educational needs in England and additional support needs in Scotland. Here, we present findings from a
Weedon, Elisabet, Riddell, Sheila
core  

Sexual and reproductive health and rights in anticipatory action for disasters. [PDF]

Disasters
Shimmin EE, Raju E.
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Socioeconomic and geographic inequalities in unmet healthcare needs in Cambodia: evidence from a national cross-sectional study. [PDF]

Int J Equity Health
Maung KT, Hunsberger M, Sopheab H, Ng N, Santosa A.   +4 more
europepmc   +1 more source