Results 1 to 10 of about 431 (87)

The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study [PDF]

Frontiers in Immunology
IntroductionMurine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma.
Juhina Das, Saurav Bera, Nilanjan Ganguly, Ipsita Guha, Tithi Ghosh Halder, Avishek Bhuniya, Partha Nandi, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Tapasi Das, Saptak Banerjee, Sandip Ghose, Anamika Bose, Anamika Bose, Rathindranath Baral   +15 more
doaj   +4 more sources

Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades [PDF]

Frontiers in Oncology, 2020
Neem Leaf Glycoprotein (NLGP) is a natural immunomodulator, have shown sustained tumor growth restriction as well as angiogenic normalization chiefly by activating CD8+ T cells.
Akata Saha, Partha Nandi, Shayani Dasgupta, Avishek Bhuniya, Nilanjan Ganguly, Tithi Ghosh, Ipsita Guha, Saptak Banerjee, Rathindranath Baral, Anamika Bose   +9 more
doaj   +2 more sources

Neem leaf glycoprotein prophylaxis transduces immune dependent stop signal for tumor angiogenic switch within tumor microenvironment. [PDF]

PLoS ONE, 2014
We have reported that prophylactic as well as therapeutic administration of neem leaf glycoprotein (NLGP) induces significant restriction of solid tumor growth in mice.
Saptak Banerjee, Tithi Ghosh, Subhasis Barik, Arnab Das, Sarbari Ghosh, Avishek Bhuniya, Anamika Bose, Rathindranath Baral   +7 more
doaj   +2 more sources

Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells. [PDF]

PLoS ONE, 2017
Post-surgical tumor recurrence is a common problem in cancer treatment. In the present study, the role of neem leaf glycoprotein (NLGP), a novel immunomodulator, in prevention of post-surgical recurrence of solid sarcoma was examined.
Madhurima Sarkar, Sarbari Ghosh, Avishek Bhuniya, Tithi Ghosh, Ipsita Guha, Subhasis Barik, Jaydip Biswas, Anamika Bose, Rathindranath Baral   +8 more
doaj   +2 more sources

Neem leaf glycoprotein activates CD8(+) T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma. [PDF]

PLoS ONE, 2013
In spite of sufficient data on Neem Leaf Glycoprotein (NLGP) as a prophylactic vaccine, little knowledge currently exists to support the use of NLGP as a therapeutic vaccine.
Atanu Mallick, Subhasis Barik, Kuntal Kanti Goswami, Saptak Banerjee, Sarbari Ghosh, Koustav Sarkar, Anamika Bose, Rathindranath Baral   +7 more
doaj   +2 more sources

Normalization of tumor microenvironment by neem leaf glycoprotein potentiates effector T cell functions and therapeutically intervenes in the growth of mouse sarcoma. [PDF]

PLoS ONE, 2013
We have observed restriction of the murine sarcoma growth by therapeutic intervention of neem leaf glycoprotein (NLGP). In order to evaluate the mechanism of tumor growth restriction, here, we have analyzed tumor microenvironment (TME) from sarcoma ...
Subhasis Barik, Saptak Banerjee, Atanu Mallick, Kuntal Kanti Goswami, Soumyabrata Roy, Anamika Bose, Rathindranath Baral   +6 more
doaj   +2 more sources

Neem leaf glycoprotein mediated epigenetic modification in oral squamous cell carcinoma

Phytomedicine Plus, 2023
Background: Recent studies have found out that the initiation and progression of cancer, traditionally seen as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations.
Arya Chatterjee, Arunangsu Singh, Geetha Shanmugam, Sudeshna Rakshit, Latika M Mohanty, Ashok Kumar, Sitaram Harihar, Koustav Sarkar   +7 more
doaj   +3 more sources

Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB [PDF]

Cell Communication and Signaling
Background A water-soluble ingredient of mature leaves of the tropical mahogany ‘Neem’ (Azadirachta indica), was identified as glycoprotein, thus being named as ‘Neem Leaf Glycoprotein’ (NLGP).
Nilanjan Ganguly, Tapasi Das, Avishek Bhuniya, Ipsita Guha, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Saurav Bera, Jesmita Dhar, Shayani Dasgupta, Akata Saha, Tithi Ghosh, Juhina Das, Ugir Hossain Sk, Saptak Banerjee, Subrata Laskar, Anamika Bose, Rathindranath Baral   +17 more
doaj   +2 more sources

Neem (<i>Azadirachta indica</i>): A Miracle Herb; Panacea for All Ailments. [PDF]

Food Sci Nutr
This comprehensive review highlights the diverse phytochemicals derived from neem leaves, extraction techniques, and their medicinal value in the treatment of multiple medical conditions. This miraculous plant has significant potential for enhanced effectiveness.
Tufail T, Bader Ul Ain H, Ijaz A, Nasir MA, Ikram A, Noreen S, Arshad MT, Abdullahi MA.   +7 more
europepmc   +2 more sources

Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of <i>Azadirachta indica</i> Phytoconstituents Using In Vitro and In Silico Approaches. [PDF]

Food Sci Nutr
The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico methodologies. Sarcoptes scabiei were stimulated with Azadirachta indica at four concentrations (25–100 mg/mL) at different intervals.
Fatima T, Abbas M, Zafar K, Zafar MG, Haider W, Zafar MH, Riaz M, Iqbal M, Mtewa AG.   +8 more
europepmc   +2 more sources