Results 31 to 40 of about 8,918 (170)

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 23: Suitability of taxonomic units notified to EFSA until September 2025

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

Sodium–glucose co‐transporter 2 inhibitors in severe estimated glomerular filtration rate deterioration across cardiovascular‐kidney‐ metabolic conditions: A pooled analysis of randomized trials

European Journal of Heart Failure, Volume 27, Issue 11, Page 2433-2441, November 2025.
Aims The efficacy of sodium–glucose co‐transporter 2 inhibitors (SGLT2i) among patients with cardiovascular‐kidney‐metabolic (CKM) conditions who experience severe estimated glomerular filtration rate (eGFR) deterioration during follow‐up is not well established.
João Pedro Ferreira, Pedro Marques, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Abhinav Sharma, Francisco Vasques‐Nóvoa, Luís Mendonça, João Sérgio Neves, Milton Packer, Faiez Zannad   +10 more
wiley   +1 more source

Raised questions about the proposed adjustment in CKD classification in the elderly

Brazilian Journal of Nephrology
In a recent review article, authors suggest lowering the diagnostic threshold for chronic kidney disease (CKD) in the elderly population. Here, it is discussed the possible implications of that proposed change.
José Andrade Moura Neto
doaj   +1 more source

Comorbidity and Malnutrition as Key Determinants of Mortality in Elderly Haemodialysis Patients: A One‐Year Observational Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background In elderly haemodialysis patients, poor functional status correlates with malnutrition, morbidity and mortality. This study aimed to assess 1‐year survival in an elderly haemodialysis population and evaluate the predictive capacity of commonly used scales for comorbidity, malnutrition, dependence and frailty.
M. L. Sanchez‐Tocino, S. Mas‐Fontao, E. González‐Parra, P. Manso, M. Burgos, D. Carneiro, M. Pereira, C. Pereira, A. Lopez‐González, M. D. Arenas, on behalf the renal foundation work team   +10 more
wiley   +1 more source

Importância da avaliação bioquímica mensal na triagem de pacientes com desnutrição em hemodiálise

Brazilian Journal of Nephrology, 2010
INTRODUÇÃO: A desnutrição é uma complicação frequente nos pacientes em hemodiálise, sendo o diagnóstico precoce importante para reduzir as taxas de morbidade e mortalidade do tratamento.
Manuel Carlos Martins de Castro, Flávia Chiaradia Andrade de Oliveira, Ana Castello Branco da Silveira, Kátia de Barros Correia Gonzaga, Magdaleni Xagoraris, Jerônimo Ruiz Centeno, José Adilson Camargo de Souza   +6 more
doaj   +1 more source

STING inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis

The Journal of Pathology, Volume 267, Issue 2, Page 196-212, October 2025.
Abstract Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultimately, discontinuation of PD.
Vanessa Marchant, Jorge García‐Giménez, Guadalupe T González‐Mateo, Pilar Sandoval, Lucía Tejedor‐Santamaria, Sandra Rayego‐Mateos, Ricardo Ramos, José A Jiménez‐Heffernan, Alberto Ortiz, Anne‐Catherine Raby, Manuel López‐Cabrera, Adrián M Ramos, Marta Ruiz‐Ortega   +12 more
wiley   +1 more source

Caracterização dos pacientes portadores de insuficiência renal atendidos na emergência de um hospital geral [Characterization of patients with renal failure treated at a general hospital emergency department]

Revista Enfermagem UERJ, 2015
As unidades de saúde que prestam atendimento de emergência devem estar preparadas para o atendimento a pacientes em insuficiência renal aguda, visto que o diagnóstico, escolha do método dialítico, preparo do paciente e acesso venoso adequado precoces são
Eduardo Tavares Gomes, Mônica de Melo Macêdo Papaleo   +1 more
doaj   +3 more sources

Proteinúria: Como valorizar o seu significado

Revista Portuguesa de Medicina Geral e Familiar, 2008
Introdução: A proteinúria é um achado laboratorial comum em adultos assintomáticos, que em circunstância alguma deve ser menosprezado. A utilização de tiras teste é o método mais utilizado na detecção da proteinúria, mas, como apresenta uma elevada ...
Francisco Ferrer, Nuno Oliveira, Karina Lopes, Ana Figueiredo, Pedro Maia, Armando Carreira   +5 more
doaj   +1 more source

Associated Factors to Nonadherence to Routine Appointments after Kidney Transplantation: The ADHERE Brazil Study

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Rationale Nonadherence to routine outpatient appointments (NApp) post kidney transplantation (KT) is a poorly studied health behavior associated with unfavorable outcomes. In the ADHERE BRAZIL Study, we previously reported a high prevalence of this behavior (12.7%).
Roberta Lopes Karlburger, João Henrique Sendrete de Pinho, Fernando Antônio Basile Colugnati, Kris Denhaerynck, José Osmar Pestana Medina, Tainá Veras de Sandes‐Freitas, Sabina De Geest, Helady Sanders‐Pinheiro, the ADHERE BRAZIL Study Team   +8 more
wiley   +1 more source