Results 31 to 40 of about 3,104 (224)

Molecular Determinants of Nef Function

Journal of Biomedical Science, 1997
The human immunodeficiency virus (HIV), the causative agent of the acquired immune deficiency syndrome (AIDS), in addition to encoding for the gag, pol and env structural genes common to all retroviruses also encodes six accessory genes: tat, rev, nef, vpr, vpu and vif. These accessory genes are responsible for the regulation of HIV replication. Recent
T., Luo, J.L., Foster, J.V., Garcia
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Tasavvuf Düşüncesinde Nefs: Bibliyometrik Analiz ve Akademik Eğilimler

Bozok Üniversitesi İlahiyat Fakültesi Dergisi
Bu çalışma, İslam düşüncesinin temel kavramlarından biri olan “nefs”i bibliyometrik analiz yöntemiyle disiplinler arası bir perspektifte ele almaktadır.
Edibe Taş, Nuriye İnci
doaj   +1 more source

The Term “Nafs” in The Qur’ān

Kader, 2023
The definition, nature, characteristics, and identification of the nafs are among the most fundamental problems in both metaphysics and theology. The manner in which the subject of the nafs is addressed even provides the opportunity to scrutinize the ...
Tuğba Günal
doaj   +1 more source

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

NECMEDDÎN-İ DÂYE RÂZÎ’NİN (ö. 654/1256) MEBDE ve MEÂD ANLAYIŞINDA NEFSİN YERİ

Kilis 7 Aralık Üniversitesi İlahiyat Fakültesi Dergisi
Necmeddîn-i Dâye XIII. yüzyılda Moğol istilasından kaçarak Anadolu’ya gelmiş ve en tanınan eseri Mirsâdü’l-ibâd’ı burada yazmıştır. Erken dönemlerde Farsçadan Türkçeye tercüme edilen eser, Türk okuyucusundan bir hayli rağbet görmüş, dolayısıyla Mirsâd’ın
Hatice Çubukcu
doaj   +1 more source

Nefs, Akıl Ve Gönül Kavramlarını İd, Ego, Süperego Bağlamında Okuma Denemesi: Fuzûlî Divanı Örneği

Kocatepe İslami İlimler Dergisi, 2021
Özünde insanın anlamaya ve açıklamaya çalıştığı benliğini, bilim adamları ve sanatçılar, çoğu zaman farklı kavramları kullanarak aynı şekilde izah eder.
Ruken Karaduman
doaj   +1 more source

Modeling the Nexus Between Climate Risk, Energy Consumption, and Financial Market Performance in Emerging Countries

International Studies of Economics, EarlyView.
Abstract This paper examines the link between climate risk, energy consumption, and financial market performance in a sample of emerging countries over the period 2000–2024. The objective is to model the dynamic interactions between these three dimensions, in order to understand the extent to which energy dependence and exposure to climate risks ...
Abdelkader Mohamed Derbali
wiley   +1 more source

Şahkerim Kudayberdiulı’nın Eserlerinde Tasavvufî Unsurlar: Ruh, Nefs ve Kalp

Danisname Beşeri ve Sosyal Bilimler Dergisi, 2022
Kazak halkının yer altı ve yer üstü kaynaklarını ele geçirmek ve sömürmek için, Rus Çarlığı ve Sovyetler Birliği’nin ilk olarak bu hazinenin sahibi olan Kazak halkını milli ve manevî değerlerinden ayırması gerekirdi. Bunun için yapılması gereken ilk şey,
Saltan Saken
doaj   +1 more source