Results 101 to 110 of about 2,384,002 (300)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Collaborative Suppression Strategy for AC Asymmetric Faults in Offshore Wind Power MMC-HVDC Systems

Energies
When offshore wind power is connected to a grid via Modular multilevel converter-based High Voltage Direct Current (MMC-HVDC), the sending-end alternating current (AC) system is susceptible to asymmetrical faults. These faults lead to overcurrent surges,
Xiang Lu, Chenglin Ren, Shi Jiao, Jie Shi, Weicheng Li, Hailin Li   +5 more
doaj   +1 more source

Compensation of negative sequence stator flux of doubly-fed induction generator using polar voltage control-based direct torque control under unbalanced grid voltage condition

The Journal of Engineering, 2015
This study proposes a polar voltage control-based direct torque control method to reduce the effects of unbalanced grid voltage on doubly-fed induction generator (DFIG)-based wind turbine system.
Badrinarayan Bansilal Pimple, Vishal Yashwant Vekhande, Baylon G. Fernandes   +2 more
doaj   +1 more source

Metabolic characteristics and genomic epidemiology of Escherichia coli serogroup O145 : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand [PDF]

, 2018
Shiga toxin-producing Escherichia coli (STEC) are a global public health concern, and can cause severe human disease. Ruminants are asymptomatic reservoirs of STEC, shedding this pathogen via their faeces.
Collis, Rose
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Calculation Method and Characteristic Analysis for Fault Current of Permanent Magnet Direct-Drive Wind Power System considering Positive and Negative Sequence Decomposition

International Transactions on Electrical Energy Systems
In view of the fact that the influence of positive and negative sequence decomposition, which is widely used in positive and negative sequence decoupling control in control system, on the fault current calculation process is not deeply considered in the ...
Botong Li, Qing Zhong, Weijie Wen, Bin Li, Xiaolong Chen   +4 more
doaj   +1 more source

Control strategy for microgrid under three-phase unbalance condition

Journal of Modern Power Systems and Clean Energy, 2016
Microgrid (MG) is generally developed at utility terminal which contains lots of unbalanced loads and distributed generations (DGs). The interaction between MG and the unbalance loads or DGs will degrades the control performance of interfaced inverter in
Hongtao Shi, Fang Zhuo, Hao Yi, Zhiqing Geng   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source