Results 71 to 80 of about 2,384,002 (300)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A multifunctional dynamic voltage restorer for power quality improvement [PDF]

, 2018
Power quality is a major concern in electrical power systems. The power quality disturbances such as sags, swells, harmonic distortion and other interruptions have an impact on the electrical devices and machines and in severe cases can cause serious ...
Dung, Vo Tien, Goňo, Radomír, Leonowicz, Zbigniew   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Line-start permanent-magnet motor single-phase steady-state performance analysis [PDF]

, 2003
This paper describes an efficient calculating procedure for the steady-state operation of a single-phase line-start capacitor-run permanent-magnet motor.
Cossar, C., McGilp, M.I., Miller, T.J.E., Popescu, M., Santarossa, R., Strappazzon, G., Trivillin, N.   +6 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Study on the calculation method of electrical quantity for connection line open-phase operation of wind farm connected to MMC-HVDC Considering negative sequence current suppression

International Journal of Electrical Power & Energy Systems
The open-phase operation of the AC connection line connecting the wind farm and MMC generates negative sequence current in the system, which cause the overcurrent, overvoltage, power fluctuation and other problems.
Botong Li, Yuejin Dong, Xinru Jiao, Xiaolong Chen, Bin Li, Liang Ji   +5 more
doaj   +1 more source

ERP analysis of cognitive sequencing : a left-anterior negativity related to structural transformation processing [PDF]

, 2000
A major objective of cognitive neuroscience is to identify those neurocomputational processes that may be shared by multiple cognitive functions vs those that are highly specifc.
Dominey, Peter-Ford, Hoen, Michel
core  

Stars of extragalactic origin in the solar neighborhood [PDF]

, 2004
We computed the spatial velocities and the galactic orbital elements using Hipparcos data for 77 nearest main-sequence F-G-stars with published the iron, magnesium, and europium abundances determined from high dispersion spectra and with the ages ...
B. Edvardsson, B. M. Tinsley, B. W. Carney, B. W. Carney, C. Allen, C. Palma, D. A. Berg Vanden, D. A. Berg Vanden, D. Dinescu, D. Dinescu, D. L. Barris, F.-K. Thielemann, G. Gilmore, J. Bernkoff, J. C. Wheeler, K. Freeman, K. Furmann, L. Mashonkina, L. Mashonkina, L. R. King, Larson, M. Barbier-Brossat, M. Bellazini, M. Mateo, O. J. Eggen, O. Yu. Gnedin, R. B. Hanson, R. Ibata, S. Bergh van den, S. Leon, T. Tshuchiya, T. V. Borkova, T. V. Borkova, T. V. Borkova, T. V. Borkova, V. A. Marsakov, V. A. Marsakov   +36 more
core   +2 more sources