Results 171 to 180 of about 14,118,684 (408)
Association of hypotension with positive and negative affect and depressive symptoms in the elderly [PDF]
, 2001 Anthony F. Jorm
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Fibre components negatively affect ileal protein digestibility in pigs [PDF]
, 2001 L. Buraczewska
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Negative partisanship and affective polarization
Research on the roots of affective polarization has often emphasized the role played by social identities, whereby identifying with a political party may lead to hostility towards the ‘other side’ of politics. Whilst fruitful, this approach does not account for the many citizens who feel strongly repelled by a particular party and yet feel attached to ...
Luana Russo, João Areal
openaire +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
RISK AND STRUCTURAL CHANGE IN AGRICULTURE: HOW INCOME SHOCKS INFLUENCE FARM SIZE [PDF]
Farm-level Census data and county-level income shock data reveal that past unexpected income shocks affect the rate of change in average farm size. Average farm size increases more quickly in counties experiencing negative income shocks as compared to ...
Key, Nigel D., Roberts, Michael J.
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Salience of positive and negative affect in the recognition of depression among elderly persons
, 1999 Tina L. Harralson, M. Powell Lawton
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Serine 577 Is Phosphorylated and Negatively Affects the tRNA Binding and eIF2α Kinase Activities of GCN2 [PDF]
, 2002 Minerva T. Garcia-Barrio +8 more
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