Results 261 to 270 of about 14,118,684 (408)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Bidirectional Dynamics Between Stress-Reactive Rumination and Negative Affect: Evidence From a Multimethods Study in Individuals With High Trait Anxiety. [PDF]

Depress Anxiety
Qingzi Z, Lanxin P, Lijing N, Yuanyuan Z, Xiayan C, Zini C, Haowei D, Ruibin Z.   +7 more
europepmc   +1 more source

The negatively charged C-terminal of tubulin affects the binding rate of kinesin.

, 2003
Miho Katsuki, Seiichi Uchimura, Itsushi Minoura, Jun‐ichi Nikawa, E. Muto   +4 more
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Negative affect prior to and following overeating-only, loss of control eating-only, and binge eating episodes in obese adults.

International Journal of Eating Disorders, 2015
Kelly C Berg, R. Crosby, L. Cao, S. Crow, S. Engel, S. Wonderlich, C. Peterson   +6 more
semanticscholar   +1 more source

Understanding the effect of the caring dimension of PYD on depression: the role of positive and negative affect regulation strategies in Spanish emerging adults. [PDF]

BMC Psychol
Gomez-Baya D, Gaspar de Matos M, Wiium N.   +2 more
europepmc   +1 more source

Positive and negative affect differentially influence identification of facial emotions

, 2004
Nicholas J. Coupland, Ryan A. Sustrik, Patricia T. Ting, Daniel Li, Misha A. W. Hartfeil, Anita J. Singh, James Blair   +6 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Preoperative Opioid Misuse Associations With Delayed Opioid Cessation, Pain, and Negative Affect After Spine Surgery. [PDF]

Neurospine
Hah JM, Levine SC, Khairnar S, Pirrotta L, Ben-Natan AR, Tse E, Hettie G, Alamin T, Veeravagu A, Hu S, Hernandez-Boussard T.   +10 more
europepmc   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source