Results 81 to 90 of about 2,547,134 (311)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Designing and Testing Causal Model of Relation between Confronting Styles and Positive and Negative Affection and Forgiveness in Students

روانشناسی بالینی و شخصیت, 2013
This study was conducted aimed at designing and testing causal model of relation between confronting styles and positive and negative affection and forgiveness in students of university.
S. bassak nejad, F. Amini, E. Hashemi Sheykh shabani   +2 more
doaj  

Affect intensity contributes to perfectionistic self-presentation in adolescents beyond perfectionism [PDF]

, 2014
Perfectionistic self-presentation in adolescents is associated with psychological maladjustment and distress. Yet, no study so far has investigated what personality characteristics contribute to perfectionistic self-presentation in adolescence.
Stoeber, Joachim, Danielle L. Roche, Roche, Danielle L., Joachim Stoeber   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Education and Income Predict Future Emotional Well-Being of Whites but Not Blacks: A Ten-Year Cohort

Brain Sciences, 2018
Background: The Minorities’ Diminished Return (MDR) theory is defined as systematically smaller effects of socioeconomic status (SES) on the health and well-being of minority groups when compared to Whites.
Shervin Assari, Brianna Preiser, Marisa Kelly   +2 more
doaj   +1 more source

Bad moods and attitudes: Neural correlates of state and trait negative affect

, 2011
Trait and state negative affect contribute to the development and maintenance of psychopathology, though the mechanisms through which they exert their effects remain unclear.
Crocker, Laura D.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigation Of The Prevalence Of Musculoskeletal Disorders And Its Relationship With Negative Affect In Nurses: A Descriptive-Analytical Study

طب کار, 2021
Background and Aim: The effect of musculoskeletal disorders and its association with negative affect in nurses has been less studied; Due to the need to find practical factors in preventing musculoskeletal disorders, the present study conducted to ...
Khalil BorhanZehi, Zahra Ebrahimi rigi, Elnaz YazdanParast, Saiede Dadpishe, Hajare Ebrahimi rigi   +4 more
doaj  

A prospective study investigating the impact of school belonging factors on negative affect in adolescents

, 2011
School belonging, measured as a unidimensional construct, is an important predictor of negative affective problems in adolescents, including depression and anxiety symptoms. A recent study found that one such measure, the Psychological Sense of School
Michael J. Furlong, Ross Homel, Ian M. Shochet, J. Furlong, Michael, Furlong, MJ, Smith, Coral L., Furlong, Michael J., Shochet, IM, M. Shochet, Ian, Coral L. Smith, Shochet, Ian M., Homel, R, Homel, Ross, L. Smith, Coral, Smith, CL   +14 more
core   +1 more source