Results 41 to 50 of about 377,610 (328)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
On a flexible construction of a negative binomial model [PDF]
, 2019 This work presents a construction of stationary Markov models with negative-binomial marginal distributions. A simple closed form expression for the corresponding transition probabilities is given, linking the proposal to well-known classes of birth and ...
Leisen, Fabrizio +3 more
core +3 more sources
On a Bivariate Poisson Negative Binomial Risk Process
Biomath, 2014 In this paper we define a bivariate counting process as a compound Poisson process with bivariate negative binomial compounding distribution. We investigate some of its basic properties, recursion formulas and probability mass function.
Krasimira Kostadinova, Leda Minkova
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Group sequential designs for negative binomial outcomes
, 2018 Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis, the number of hospitalizations in heart failure, and the number of ...
Friede, Tim +3 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
On the Accuracy of the Generalized Gamma Approximation to Generalized Negative Binomial Random Sums
Mathematics, 2021 We investigate the proximity in terms of zeta-structured metrics of generalized negative binomial random sums to generalized gamma distribution with the corresponding parameters, extending thus the zeta-structured estimates of the rate of convergence in ...
Irina Shevtsova, Mikhail Tselishchev
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Transform methods for testing the negative binomial hypothesis
Statistica, 2007 We employ the empirical probability generating function in constructing a goodness-of-fit test for negative binomial distributions. The proposed tests, which are formed as weighted integrals, are shown to be consistent and their asymptotic null ...
Simos G. Meintanis
doaj +1 more source
An Overview of Modern Applications of Negative Binomial Modelling in Ecology and Biodiversity
Diversity, 2022 Negative binomial modelling is one of the most commonly used statistical tools for analysing count data in ecology and biodiversity research. This is not surprising given the prevalence of overdispersion (i.e., evidence that the variance is greater than ...
Jakub Stoklosa +2 more
doaj +1 more source