Results 221 to 230 of about 15,765,091 (307)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dominant-Negative Effects of p53 R337 Variants in Li-Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity. [PDF]

Chembiochem
Kamada R, Sakaguchi S, Kanno M, Ozawa T, Nakagawa N, Omichinski JG, Sakaguchi K.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Magnesium application partially reversed the negative effects of mulching on rhizosphere nitrogen cycling in a <i>Phyllostachys praecox</i> forest. [PDF]

Front Plant Sci
Zhao H, Kuang X, Li Y, Li T, Wang T, Yu L, Xia C, Dong H, Shen J, Fu B, Zhou H.   +10 more
europepmc   +1 more source

On Negative Intervention Effects

On Negative Intervention Effects
2 KJ00004869061 論説 ...
openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome. [PDF]

Am J Physiol Endocrinol Metab
Kilroe SP, Von Ruff ZD, Arentson-Lantz EJ, Romsdahl TB, Linares JJ, Kalenta H, Marchant ED, Volpi E, Paddon-Jones D, Russell WK, Rasmussen BB.   +10 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Exogenously applied putrescine and chitosan-putrescine nanocomposite alleviate the negative effects of chilling stress on iceberg lettuce seedlings. [PDF]

Sci Rep
Kalisz A, Kornaś A, Gil J, Sękara A, Húska D, Rudolphi-Szydło E, Sieprawska A, Gawrońska K, Kulak M, Fotopoulos V, Gohari G.   +10 more
europepmc   +1 more source