Results 61 to 70 of about 313,192 (313)

Technology strategies for low-carbon economic growth: a general equilibrium assessment [PDF]

, 2016
This paper investigates the potential for developing countries to mitigate greenhouse gas emissions without slowing their expected economic growth. A theoretical frame- work is developed that unifies bottom-up marginal abatement cost curves and partial ...
Sue Wing, Ian, Timilsina, Govinda R.
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The role of negative emissions technologies in the UK’s net-zero strategy

Cell Reports Sustainability
Summary: The role of negative emissions technologies (NETs) in climate change mitigation remains contentious. Although numerous studies indicate significant carbon dioxide removal (CDR) requirements for Paris Agreement mitigation goals to be achieved ...
Semra Bakkaloglu, Matthias Mersch, Nixon Sunny, Christos N. Markides, Nilay Shah, Adam Hawkes   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Modulating Electronic States of Cu in Metal‐Organic Frameworks for Emerging Controllable CH4/C2H4 Selectivity in CO2 Electroreduction

Advanced Science
The intensive study of electrochemical CO2 reduction reaction (CO2RR) has resulted in numerous highly selective catalysts, however, most of these still exhibit uncontrollable selectivity.
Mingxu Sun, Jiamin Cheng, Akihiko Anzai, Hirokazu Kobayashi, Miho Yamauchi   +4 more
doaj   +1 more source

Don’t deploy negative emissions technologies without ethical analysis [PDF]

Nature, 2018
Climate policy advice is being undermined by value-laden choices over risky mitigation strategies, warn Dominic Lenzi and colleagues. Climate policy advice is being undermined by value-laden choices over risky mitigation strategies, warn Dominic Lenzi and colleagues.
Dominic Lenzi, William F. Lamb, Jérôme Hilaire, Martin Kowarsch, Jan C. Minx   +4 more
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Greening Capitalism? A Marxist Critique of Carbon Markets [PDF]

, 2012
Climate change is increasingly being recognized as a serious threat to dominant modes of social organization, inspiring suggestions that capitalism itself needs to be transformed if we are to ‘decarbonize’ the global economy. Since the Kyoto Protocol in
Abate R. S., Arrighi G., Bernstein S., Bond P., Bruno K., Bueno F. M., Chatterjee P., De Angelis M., Foster J. B., Foster J. B., Foster J. B., Ghosh S., Giddens A., Gilbertson T., Grubb M., Guha R., Haque U., Harvey D., Harvey D., Heartfield J., Korten D., Lohmann L., Marini R. M., Marx K., Marx K., Marx K., Marx K., Moyo S., O’Connor J., Porter M. E., Pouchepadass J., Schlup M., Tietenberg T. H., UNCED (United Nations Conference on Environment and Development), UNCED (United Nations Conference on Environment and Development), World Commission on Environment and Development, Yamin F.   +36 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source