Results 101 to 110 of about 6,536,054 (294)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Visual signals and children's communication: negative effects on task outcome [PDF]

, 2000
Previous research has found that young children fail to adapt to audio-only interaction (e.g. Doherty-Sneddon & Kent, 1996), and perform difficult communication tasks better face-to-face. In this new study, children aged 6- and 10 year-olds were compared
Blokland, A., McAuley, Sandra, Anderson, Anne, Blokland, Arjan, Doherty-Sneddon, Gwyneth, Anderson, Anne H, Langton, Stephen, Bruce, Vicki   +7 more
core   +1 more source

Riding with respect: politeness in conversation between bodaboda riders and their clients in Mbooni Sub-County, Makueni, Kenya

Cogent Arts & Humanities
This study investigated the use of politeness strategies in the interactions between bodaboda riders and their clients in Mbooni Sub-County, Makueni, Kenya. A qualitative research approach, utilizing purposive sampling, was employed.
Faith Mbithe Kathukya, John Khaisie Wanyama, Timothy Kinoti M’Ngaruthi   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An experimental test of the effects of online and face-to-face feedback on self-esteem

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace, 2017
This study investigated the effect of receiving confirming vs. disconfirming feedback to individuals’ self-disclosure on their self-esteem, the role of giving reciprocal feedback in this relationship, and how these effects differ between online and face-
Helen G. M. Vossen, Maria Koutamanis, Joseph B. Walther   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ottavo Colloquio di Musicologia del "Saggiatore musicale"

, 2004
Prolusione di G. La Face "Una stella e il suo futuro" (in occasione del decennale del "Saggiatore musicale"). Due tavole rotonde: "La musica nel cinema: il problema del ritmo " (coordinatori G. Manzoli, UniBo, e C.
LA FACE, GIUSEPPINA
core   +1 more source

Politeness Strategies Used in the Iranian and American Newspapers: The Case of Iran's Nuclear Deal

Research in English Language Pedagogy
The appropriate employment of language by politicians can settle many of the current global problems and crises. Iran’s nuclear deal with all its complexities and subtleties is one of the most contentious global issues that demands a lot of tact and ...
Rasoul Mohammad Hosseinpur, Maryam Sadat Sadat Hosseini   +1 more
doaj