Results 121 to 130 of about 427,941 (305)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Negative Ions May Induce Lucidity

, 1981
An attempt to determine if an environment containing 104 negative ions per cubic centimeter would promote lucidity yielded negative ...
Adler, Tom
core  

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

A novel helicon plasma source for negative ion beams for fusion [PDF]

, 2016
International audienceIn DEMO and future nuclear fusion reactors to produce economically competitive electricity, neutral beam (NB) systems will be required, delivering up to 150 MW of high neutral particle energy (1 MeV) with high wall-plug efficiency ...
Usel, Fantz, Howling, A.A., Howling, Alan, Dirk, Wünderlich, Wünderlich, D., Duval, Basil, Duval, B.P., Guittienne, Ph., Marini, C., Furno, I., Agnello, Riccardo, Fantz, U., Béchu, Stéphane, Marini, Claudio, Jacquier, Rémy, Agnello, R., Simonin, A., Stephane, Béchu, Alain, Simonin, Furno, Ivo, Guittienne, Philippe, Jacquier, R.   +21 more
core  

Spherical nonthermal pulsational mode stability thermo-statistically moderated with extra-negative ions

Fundamental Plasma Physics
The presence of diverse negative ions is well-known to modify different collective waves and instabilities in diverse space and astrophysical environments.
Jonmoni Dutta, Ahmed Atteya, Pralay Kumar Karmakar   +2 more
doaj   +1 more source

Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. [PDF]

Rapid Commun Mass Spectrom, 2021
Hale OJ, Ryumin P, Brown JM, Morris M, Cramer R.   +4 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Some Electron Detachment Data for H^- Ions in Collisions with Electrons, Ions, Atoms and Molecules - an Alternative Approach to High Energy Neutral Beam Production for Plasma Heating - [PDF]

, 1990
In order to provide information on the effectiveness of the conversion of negative hydrogen ions in collision with multiply charged ions into neutrals for plasma heating, the present situation is reviewed on the cross sections involving negative hydrogen
TAWARA, Hiro, TAWARA, Hiroyuki
core  

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source