Results 41 to 50 of about 1,955 (248)

Negative partisanship and the populist radical right: The case of Norway

Scandinavian Political Studies, 2023
AbstractWith the rise and influence of populist radical right (PRR) parties in Western European democracies, research has focused on explaining the PRR vote. We know less about the reasons why many people would never vote for these parties. Recent research has pointed out that negative partisanship may be particularly prominent in the case of PRR ...
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Negative Partisanship in a Multi-party System: The Case of Canada

Journal of Elections, Public Opinion and Parties, 2015
The origins and implications of partisan identification are well studied, but negative partisan attitudes – dislike for a particular party – have escaped such scrutiny. We argue that the concept of partisanship, especially in a multi-party system, is incomplete until negative sentiments are considered.
Michael McGregor, R., J. Caruana, Nicholas, B. Stephenson, Laura   +2 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Development and Validation of the Affective Polarization Scale

International Review of Social Psychology
Affective polarization – an expressed aversion and dislike of members of one’s political outgroup – has increased in many polities in recent years, and thus published research on the topic has proliferated.
Brandon McMurtrie, Michael Philipp, Ross Hebden, Matt Williams   +3 more
doaj   +1 more source

Mudslinging on Twitter During the 2014 Election

Social Media + Society, 2017
Following the work of Evans, Cordova, and Sipole, we examine the way that candidates for congressional seats in 2014 used Twitter during the last 2 months of their campaign.
Heather K. Evans, Sean Smith, Alexis Gonzales, Kayla Strouse   +3 more
doaj   +1 more source

Individual narcissism, need for closure and the two sides of negative partisanship

, 2021
Usual studies of the underpinnings of partisan attachments only consider positive party identifications and the Big Five framework. However, negative party identification is an important understudied side of party identification that affects democratic dissatisfaction and political conflict.
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source