Results 131 to 140 of about 3,728 (241)

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

open access: yesAdvanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen   +14 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Origami Metamaterials Based on Low‐Melting‐Point Alloy Phase Transition: Breaking the Trade‐Off Between Reusability and Energy Absorption Quality

open access: yesAdvanced Science, EarlyView.
This work presents an origami metamaterial that integrates a low‐melting‐point alloy skeleton into an elastomeric shell. It dissipates energy through the metal's plastic deformation and recovers through the solid–liquid phase transition of the alloy together with the hyperelasticity of the shell.
Yupeng Liu   +5 more
wiley   +1 more source

Charge‐Transfer‐Mediated Boron Magneto‐Ionics: Towards Voltage‐Driven Multi‐Ion Transport

open access: yesAdvanced Science, EarlyView.
This study demonstrates voltage‐driven multi‐ion transport in FeBO systems, revealing simultaneous motion of B, Fe, and O ions enabled by charge‐transfer effects. By tuning oxidation states through oxygen incorporation, we achieve a transition from electrostatic‐like to electrochemical magneto‐ionic behavior. The findings establish boron magneto‐ionics,
Zheng Ma   +15 more
wiley   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

open access: yesAdvanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku   +4 more
wiley   +1 more source

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