Results 201 to 210 of about 3,728 (241)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Inherently Disordered Auxetic Metamaterials. [PDF]

Adv Sci (Weinh)
Montanari M, Moghimimonfared R, Spaggiari A, Mizzi L.   +3 more
europepmc   +1 more source

Copula‐based joint modelling of emergency department visits with time‐varying dependence

Canadian Journal of Statistics, EarlyView.
Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley   +1 more source

Photometric Diagnostic of the Sheath Dynamics and Electron Density Trends in Single and Dual Frequency CCRF Argon Plasmas

Contributions to Plasma Physics, EarlyView.
ABSTRACT A methodological study is presented on a noninvasive photometric diagnostic for determining trends in electron density and sheath dynamics in single (1f) and a dual (2f) radio frequency capacitively coupled (CCRF) argon plasmas. The 1f discharges are operated at 13.56 and 27.12 MHz, respectively, while the 2f discharge is driven by both ...
Daniel Zuhayra, Jessica Niemann, Viktor Schneider, Holger Kersten   +3 more
wiley   +1 more source

Generalized Chemical Model for Warm Dense Hydrogen: Ionization Potential Depression and Molecular Dissociation Shifts

Contributions to Plasma Physics, EarlyView.
ABSTRACT Warm dense matter (WDM) is a complex state, where quantum effects, thermal excitations, and strong interparticle correlations coexist. Understanding its microscopic composition and medium‐induced modifications of atomic and molecular properties is essential for planetary modeling, fusion research, and high‐energy‐density experiments.
L. T. Yerimbetova, Yu. V. Arkhipov, Ye. S. Mukhametkarimov, A. E. Davletov, I. M. Tkachenko   +4 more
wiley   +1 more source

Coincidence Detection in Flow Cytometry Using Pulse‐Shape Analysis in Polydisperse Suspensions

Cytometry Part A, EarlyView.
ABSTRACT Flow cytometers, based on an optical measurement principle, are widely used for cell characterization in a variety of medical applications. Especially in hematology, high counting accuracy is crucial. Therefore, it is essential to develop accurate but also fast coincidence correction methods.
Alexander Putz, Jonas Gienger, Martin Hussels   +2 more
wiley   +1 more source

Rapid Design and Fabrication of Body Conformable Surfaces with Kirigami Cutting and Machine Learning. [PDF]

Adv Sci (Weinh)
Bali J, Li J, Chen J, Li S.
europepmc   +1 more source

3D-MOF-Lattice Inspired Programmable Metamaterials Based on Reconfigurable Polyhedral Origami. [PDF]

Adv Sci (Weinh)
Kang X, Zhang Y, Fan H, Xu Z, Dong Y, Li B.   +5 more
europepmc   +1 more source

First-principles study of novel Cs₂LuCoH₆ and Cs₂LuZnH₆ double hydride perovskites for hydrogen storage applications. [PDF]

RSC Adv
Almufarij RS, Hayat MS, Khalil RMA, Alghamdi SM, Shokralla EA, Arayro J, Fahmy MA, Siddig MA, Samir A, Ashfaq A.   +9 more
europepmc   +1 more source

Zwitterionic Photocurable Resin for High-Resolution 3D Printing of Ultralow-Fouling Microstructures. [PDF]

Small Methods
Wang K, Hwee N, Degraff W, Biener SM, Huang S, Feng L, Watts S, Smith WL, Wang B, Chatterjee S, Heo TW, Ye J, Cheng G, Biener J, Kim S.   +14 more
europepmc   +1 more source