Results 121 to 130 of about 6,234,302 (234)

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

A composite material with Poisson’s ratio tunable from positive to negative values: an experimental and numerical study

, 2013
The Poisson’s ratio describes an extent of transverse deformation of a material when an axial strain is applied. A change of the Poisson’s ratio from positive to negative can equip a material with a set of specific properties. In this paper, a study of a
Hu, Hong, Hou, Xiaonan, Silberschmidt, Vadim   +2 more
core   +3 more sources

The structure design and application of metamaterials with negative Poisson's ratio

EPJ Applied Metamaterials
Metamaterials with negative Poisson's ratio, also called auxetic metamaterials, are artificially engineered structures or materials that possess extraordinary auxetic effect, high shear modulus, excellent impact resistance, and remarkable energy ...
Han Xu, Tian Jiahong, Zhang Zijian, Gao Guili, Xu Xiao, Sun Kai, Fan Runhua   +6 more
doaj   +1 more source

A Study on the Dynamic Forming Mechanism Development of the Negative Poisson's Ratio Elastomer Molds-Plate to Plate (P2P) Forming Process. [PDF]

Polymers (Basel), 2021
Weng YJ, Huang JC, Chen YY, Hsu ST, Zhang ZR.   +4 more
europepmc   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Negative Poisson's Ratio-Spacer Design and Its Thermo-Mechanical Coupling Analysis Considering Specific Force Output. [PDF]

Materials (Basel), 2021
Yuan Q, Zhu Y, Yan K, Cai Y, Hong J.
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Negative to zero Poisson’s ratio adjustable UV-PDMS flexible metamaterials fabricated by using 3D photolithography

Materials & Design
Mechanical metamaterials (MMs) exhibit mechanical characteristics that are challenging to achieve using existing isotropic materials. Due to their unique characteristics, MMs hold significant potential for applications in diverse fields such as space ...
Riku Ito, Yuji Takata, Yuya Tanaka, Hiroshi Toshiyoshi, Takaaki Suzuki   +4 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

The 3D-Printed Honeycomb Metamaterials Tubes with Tunable Negative Poisson's Ratio for High-Performance Static and Dynamic Mechanical Properties. [PDF]

Materials (Basel), 2021
Guo C, Zhao D, Liu Z, Ding Q, Gao H, Yan Q, Sun Y, Ren F.   +7 more
europepmc   +1 more source