Results 51 to 60 of about 436,887 (292)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enactment of Ensemble Learning for Review Spam Detection on Selected Features

International Journal of Computational Intelligence Systems, 2019
In the ongoing era of flourishing e-commerce, people prefer online purchasing products and services to save time. These online purchase decisions are mostly influenced by the reviews/opinions of others who already have experienced them.
Faisal Khurshid, Yan Zhu, Zhuang Xu, Mushtaq Ahmad, Muqeet Ahmad   +4 more
doaj   +1 more source

Do not resonate with actions: sentence polarity modulates cortico-spinal excitability during action-related sentence reading. [PDF]

PLoS ONE, 2011
BACKGROUND: Theories of embodied language suggest that the motor system is differentially called into action when processing motor-related versus abstract content words or sentences.
Marco Tullio Liuzza, Matteo Candidi, Salvatore Maria Aglioti   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Any and its ‘free choice’

Kalbotyra
Since Ladusaw (1979) the term ‘free choice indefinite’ is the generally accepted term for the meaning of any in primarily modal and generic sentences, such as Any owl hunts mice, but not for what is generally called the ‘polarity-sensitive’ or ‘negative
Johan van der Auwera
doaj   +3 more sources

Effect of Impulse Polarity on a New Grounding Device with Spike Rods (GDSR)

Energies, 2020
The characterizations of grounding systems subjected to high impulse conditions are known to be dependent on the polarity, current to peak time and discharge time, as well as the electrical properties of the soil, and the grounding electrodes themselves.
Abdul Wali Abdul Ali, Nurul Nadia Ahmad, Normiza Mohamad Nor   +2 more
doaj   +1 more source

Large-Scale Goodness Polarity Lexicons for Community Question Answering

, 2017
We transfer a key idea from the field of sentiment analysis to a new domain: community question answering (cQA). The cQA task we are interested in is the following: given a question and a thread of comments, we want to re-rank the comments so that the ...
Church Kenneth Ward, Mohammad Saif, Nakov Preslav, Pontiki Maria, Rosenthal Sara, Turney Peter D.   +5 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source