Results 71 to 80 of about 57,882 (322)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exclamative Wh-Phrases as Positive Polarity Items

Catalan Journal of Linguistics, 2008
This paper studies the island effects induced by negation in exclamative sentences. In order to explain this phenomenon, I focus on the interaction between exclamative wh-phrases and negation, showing that negation can appear in exclamative sentences ...
Raquel González Rodríguez
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Additive presuppositions are derived through activating focus alternatives [PDF]

, 2017
The additive presupposition of particles like "too"/"even" is uncontested, but usually stipulated. This paper proposes to derive it based on two properties. (i) "too"/"even" is cross-linguistically focus-sensitive, and (ii) in many languages, "too"/"even"
Szabolcsi, Anna
core  

Exploring the Local Grammar of Evaluation: The Case of Adjectival Patterns in American and Italian Judicial Discourse [PDF]

, 2014
Based on a 2-million word bilingual comparable corpus of American and Italian judgments, this paper tests the applicability of a local grammar to study evaluative phraseology in judicial discourse in English and Italian. In particular, the study compares
Barnbrook, Barnbrook, Charles Louis, Charles Louis, Charles Louis, Charles Louis, Douglas, Douglas, Francis, Francis, Francis, Francis, Gianluca Pontrandolfo, Goźdź, Goźdź, Gross, Gross, Haarman, Haarman, Harris, Harris, Heffer, Heffer, Hunston, Hunston, Hunston, Hunston, Hunston, Hunston, Hunston, Hunston, Hyland, Hyland, La, La, Lehrberger John, Lehrberger John, Martin, Martin, Mazzi, Mazzi, Mazzi, Mazzi, Ochs, Ochs, Palmer, Palmer, Partington, Partington, Sinclair, Sinclair, Stanisław Goźdź-Roszkowski, Taboada, Taboada, Thompson, Thompson, Wallace, Wallace   +57 more
core   +4 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Preverbs, Postpositions and Indefinite Pronouns in Hittite

Atti del Sodalizio Glottologico Milanese, 2017
The paper deals with the syntax of preverbs, postpositions (including postpositional phrases) and existential quantifiers/ negative polarity items in Hittite within the Minimalist Program. Their in-situ and ex-situ positions are determined.
Andrej Sideltsev
doaj   +1 more source

Medial adjunct PPs in English: implications for the syntax of sentential negation [PDF]

, 2012
This paper provides evidence that medial adjunct PPs in English are possible. On the basis of corpus data, it is shown that sentence-medial adjunct PPs are not unacceptable and are attested.
Belletti, Chomsky, Chomsky, Cinque, De Clercq, De Clercq, Emonds, Ernst, Ernst, Frey, Haegeman, Horn, Horn, Jackendoff, Jayaseelan, Karen De Clercq, Klima, Lambotte, Liliane Haegeman, McCawley, Moscati, Pittner, Quirk, Rizzi, Ross, Sinclair, Smith, Swan, Terje Lohndal, Tottie, Tubau, Zanuttini, Zeijlstra   +32 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source