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A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Negative predictive value of drug provocation tests in children

Pediatric Allergy and Immunology, 2014
AbstractBackgroundThe negative predictive value of the drug provocation test is important for both the patient and the physician. However, in children, this predictive value is unresolved.MethodsThe study included patients who had drug provocation test with a suspected drug and was diagnosed as ‘not allergic to the drug’.
Murat Capanoglu, Aysenur Kaya, Can Naci Kocabas   +2 more
exaly   +5 more sources

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Predictive Value of a Negative Exercise Electrocardiogram

Cardiology, 2008
Conventionally, if an exercise electrocardiogram does not show evidence of ischemia, the patient must have achieved at least 85% of the predicted maximum heart rate for that test to be considered negative. However, no documentation of the validity of this practice exists.
L J, Laslett, B J, Rubin, E, Bringhurst, E A, Amsterdam   +3 more
openaire   +2 more sources

The Negative Predictive Value of Typing Safe Local Anesthetics

International Archives of Allergy and Immunology, 2013
<b><i>Background:</i></b> Although allergy to local anesthetics (LA) is rare, patients often report unwanted reactions after their administration. A history of anaphylaxis or an atypical reaction related to LA is an indication for typing a safe anesthetic for future surgical or dental procedures. <b><i>Aim:</i>&
Krzysztof, Specjalski, Karolina, Kita-Milczarska, Ewa, Jassem   +2 more
openaire   +2 more sources

Using Negative Predictive Values: In Reply

Pediatrics, 2006
In Reply .— We appreciate Dr Camp's comments and her emphasis of the importance of the high negative predictive value of the Bayley Mental Developmental Index (MDI). We agree that a normal MDI of >85 at 20 months' corrected age in an extremely low birth weight (ELBW) child is highly predictive of having a normal IQ of >85 at 8 years of age …
Maureen Hack, H. Gerry Taylor, Dennis Drotar, Mark Schluchter, Deanne Wilson-Costells   +4 more
openaire   +1 more source

Negative and positive predictive values of nerve monitoring in thyroidectomy

Head & Neck, 2011
AbstractBackgroundRecurrent nerve injury is 1 of the most important complications of thyroidectomy. During the last decade, nerve monitoring has gained increasing acceptance in several centers as a method to predict and to document nerve function at the end of the operation. We evaluated the efficacy of a nerve monitoring system in a series of patients
Claudio R, Cernea, Lenine G, Brandão, Flavio C, Hojaij, Dorival, De Carlucci, José, Brandão, Beatriz, Cavalheiro, Adriana, Sondermann   +6 more
openaire   +2 more sources

Negative predictive value of procalcitonin in medullary thyroid carcinoma

Annales de biologie clinique, 2016
Calcitonin (CT), the major biochemical marker in medullary thyroid carcinoma (MTC) is prone to in vitro instability and suffers from scarcity of clinical laboratory platforms. Procalcitonin (PCT), the precursor of CT, free of these shortcomings, has been reported as a potential MTC marker.
Soo Kyung, Lim, Jérôme, Guéchot, Michel, Vaubourdolle   +2 more
openaire   +2 more sources