Results 181 to 190 of about 1,307,822 (311)

From childhood maltreatment to depression and anxiety: a network approach focusing on perceived emotional invalidation. [PDF]

BMC Psychol
Bae H, Yim M, Kim G, Hur JW.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A systemic vulnerability in child protection: the interprofessional gap in abuse and neglect recognition rooted in university curricula. [PDF]

Front Public Health
Şahin M, Kartal OY.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Longitudinal Impact of Daytime Dysfunction on Adolescent Depressive and Anxiety Symptoms: A Random Intercept Cross-Lagged Panel Study. [PDF]

Brain Behav
Zhang N, Ji C, Tang S, Li T, Wu C, Zhu Z, Li J, Huang Y, Feng D, Ding D, Wang W.   +10 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Adverse childhood experiences and cognitive outcomes among older adults in low-income and middle-income countries: a systematic review. [PDF]

BMJ Open
Ngwa CH, Abdulrahim S, Nehme R, Saad M, Kabalan M, Lteif MR, Yazbek Y, Chaaya M, Elbejjani M.   +8 more
europepmc   +1 more source

Neglected communities.

Community eye health, 2013
If we want to address neglected tropical diseases (NTDs), we have to focus on the communities affected. NTDs affect people who are neglected in a variety of ways: through poverty and lack of access to basic water and sanitation, health services, and education … In fact, just about every facet of development.
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Symptomatic iron deficiency anemia from neglected giant basal cell carcinoma

JAAD Case Reports, 2020
Leah Laageide, MD, Elizabeth Wendl, MD, Jonathan Wadle, DO, Jennifer Powers, MD   +3 more
doaj   +1 more source