Results 221 to 230 of about 1,299,940 (312)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

If you digress, shall we not neglect? Investigating the moderating role of individual cultural values while predicting job neglect among doctors as footprint of psychological contract violation. [PDF]

BMC Psychol
Ahmad MB, Rizvi F, Shakeel N, Niazi A.
europepmc   +1 more source

Measuring Neglect

PLoS Neglected Tropical Diseases, 2007
openaire   +4 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Exploring the potential of augmented reality in rehabilitation: a novel approach for post-stroke unilateral neglect. [PDF]

Front Sports Act Living
Yanzhen M, Yunhua R, Song C, Heqiong Z, Zufang Y, Wang A.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Characteristics of Older Adults With Domestic Squalor in Japan: A Cross-Sectional Study. [PDF]

Psychogeriatrics
Taomoto D, Kanemoto H, Suehiro T, Satake Y, Nakamuta N, Hotta M, Suzuki M, Yoshiyama K, Miyoshi T, Kashiwagi K, Shigenobu K, Hashimoto M, Ikeda M.   +12 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Emotional neglect in childhood modulates aperiodic offset in the left pars orbitalis in adulthood. [PDF]

Front Neurosci
Inoue S, Otsuru N, Ikarashi H, Iimuro K, Nagasaka K, Shirozu H, Onishi H.   +6 more
europepmc   +1 more source