Results 141 to 150 of about 458,223 (349)

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Neglected tropical diseases

Tropical Parasitology, 2022
openaire   +2 more sources

Epidemic intelligence data of Crimean-Congo haemorrhagic fever, European Region, 2012 to 2022: a new opportunity for risk mapping of neglected diseases. [PDF]

Euro Surveill, 2023
Fanelli A, Schnitzler JC, De Nardi M, Donachie A, Capua I, Lanave G, Buonavoglia D, Caceres-Soto P, Tizzani P.   +8 more
europepmc   +1 more source

Neglected tropical diseases and the sustainable development goals: an urgent call for action from the front line [PDF]

, 2019
Ayenew Addisu, Wim Adriaensen, Balew Arega, Mekuria Asnakew Asfaw, Ermias Diro, Amadou Garba, Desalegn Gebree, Getahun Seid, Begashaw Hailemariam, Anthony Harries, Abera Hirpa Adugna, Zeleke Ayalew Jejaw, Edward Mberu Kamau, Tigist Kelbo, Marcel Manzi, Dana Medebo Daniel, Ashok Moloo, Piero Olliaro, Philip Owiti, John C. Reeder, Mbazi Senkoro, Kuda Takarinda, Robert Terry, Collins Timire, Samson Tucho, Hannock Tweya, Wendemagegn Enbiale, Kristien Verdonck, Florian Vogt, Saskia van Henten, Johan van Griensven, Worku Bekele, María Zolfo, Rony Zachariah   +33 more
openalex   +1 more source

Large Scale In Silico Screening on Grid Infrastructures [PDF]

, 2006
Large-scale grid infrastructures for in silico drug discovery open opportunities of particular interest to neglected and emerging diseases. In 2005 and 2006, we have been able to deploy large scale in silico docking within the framework of the WISDOM ...
Breton, V., Chen, H. -Y., Ho, L. -Y., Hofmann, M., Jacq, N., Kasam, V., Lee, H. -C., Legré, Y., Lin, S. -C., Maass, A., Medernach, E., Merelli, I., Milanesi, L., Rastelli, G., Reichstadt, M., Salzemann, J., Schwichtenberg, H., Sridhar, M., Wu, Y. -T., Zimmermann, M.   +19 more
core   +2 more sources

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

neglected disease

Citation: 'neglected disease' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12690 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests
openaire   +1 more source

The Impact of Water, Sanitation, and Hygiene on Key Health and Social Outcomes: Review of Evidence [PDF]

, 2016
This evidence paper looks at 10 areas identified collaboratively with the United Nations Children's Fund (UNICEF) on which WASH can plausibly have a strong impact: diarrhea, nutrition, complementary food hygiene, female psychosocial stress, violence ...
Joanna Esteves Mills, Oliver Cumming
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Expression of Concern: Antivirus effectiveness of ivermectin on dengue virus type 2 in Aedes albopictus.

PLoS Neglected Tropical Diseases, 2022
PLOS Neglected Tropical Diseases Editors
doaj   +1 more source