Results 51 to 60 of about 457,472 (351)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Correction: Intravenous therapy duration and outcomes in melioidosis: a new treatment paradigm. [PDF]

PLoS Neglected Tropical Diseases, 2015
[This corrects the article DOI: 10.1371/journal.pntd.0003586.].
PLOS Neglected Tropical Diseases Staff
doaj   +1 more source

A mixed methods approach to evaluating community drug distributor performance in the control of neglected tropical diseases [PDF]

, 2016
BACKGROUND: Trusted literate, or semi-literate, community drug distributors (CDDs) are the primary implementers in integrated preventive chemotherapy (IPC) programmes for Neglected Tropical Disease (NTD) control.
A Wallace, AW Solomon, C Hanson, D Evans, EC Emukah, Fiona M. Fleming, FM Fleming, Fred Matovu, J Green, J Leslie, JA Wright, JC Okeibunor, JC Okeibunor, JH Kolaczinski, JH Kolaczinski, Joanne P. Webster, JS Dill, K Banek, KA Grepin, KL Leonard, Kristian S. Hansen, L Nkonki, M Callaghan, MA Bruijnzeels, MC Baker, MF Drummond, Ministry of Health, MN Katabarwa, MO Omedo, N Najnin, P Agyei-Baffour, P Akweongo, P Basinga, SC Francis, TK Ryman, UV Amazigo, V Wiseman, World Health Organisation, World Health Organisation, World Health Organization   +39 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Epidemiologia das doenças negligenciadas no Brasil e gastos federais com medicamentos [PDF]

, 2011
The World Health Organization (WHO) and Medecins Sans Frontieres recently have proposed the term neglected diseases, referring to those that have a higher occurrence in the developing countries and most neglected, exclusive of developing countries ...
Aurea, Adriana Pacheco, de Almeida, Raquel Filgueiras, de Magalhães, Luís Carlos G., dos Santos, Carolina Fernandes, Garcia, Leila Posenato   +4 more
core  

Nicotine-replacement therapy: A proven treatment for smoking cessation [PDF]

, 2010
Smoking is a major cause of cardiovascular diseases, respiratory diseases and cancer. Despite the high prevalence of smokers worldwide, smokers are often neglected and not offered effective assistance with quitting their habits. In order to overcome this
Robson, Noorzurani
core   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Disease surveillance and patient care in remote regions: an exploratory study of collaboration among healthcare professionals in Amazonia [PDF]

, 2014
The development and deployment of information technology, particularly mobile tools, to support collaboration between different groups of healthcare professionals has been viewed as a promising way to improve disease surveillance and patient care in ...
Cesario, Manuel, Luz, Saturnino, Masoodian, Masood   +2 more
core   +1 more source

Spectrally Tunable 2D Material‐Based Infrared Photodetectors for Intelligent Optoelectronics

Advanced Functional Materials, EarlyView.
Intelligent optoelectronics through spectral engineering of 2D material‐based infrared photodetectors. Abstract The evolution of intelligent optoelectronic systems is driven by artificial intelligence (AI). However, their practical realization hinges on the ability to dynamically capture and process optical signals across a broad infrared (IR) spectrum.
Junheon Ha, Yingshan Ma, Yong Nam An, Sung‐Un An, Hyeon Hak Jung, Suvi‐Tuuli Varjamo, Jiwon Yoo, Junho Min, Hanvit Kim, Faisal Ahmed, Sang Hoon Chae, Young Min Song, Weiwei Cai, Tawfique Hasan, Zhipei Sun, Dong‐Ho Kang, Hyeon‐Jin Shin, Yunyun Dai, Hoon Hahn Yoon   +18 more
wiley   +1 more source