Results 71 to 80 of about 3,023,382 (303)

Integrated dataset of screening hits against multiple neglected disease pathogens. [PDF]

, 2011
New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 ...
Clive Yeates, Mansour Nuha R., Ridley, Robert, Simon Townson, Nwaka, S, Dominique Besson, Yeates, Clive, Townson, Simon, Yeates Clive, Jean-Marc Paris, Geary Timothy, Murthy P. K., Ramirez, Bernadette, Maes, Louis, Ramirez Bernadette, Besson, D, Yousif, F, Yousif Fouad, Samje, M, Solomon Nwaka, Van Voorhis Wesley C., Ramirez, B, Misra-Bhattacharya, S, Samje, Moses, An Matheeussen, Ridley, R, Murthy, PK, Suzanne Gokool, Cho-Ngwa Fidelis, Bickle, Q, P K Murthy, Timothy Geary, Bickle Quentin, Gokool, Suzanne, Bernadette Ramirez, Fidelis Cho-Ngwa, Geary, Timothy, Paris, Jean-Marc, Geary, T, Maes, L, Paris Jean-Marc, Quentin Bickle, Fakorede, Foluke, Shailja Misra-Bhattacharya, Samje Moses, Moses Samje, Van Voorhis, WC, Bickle, Quentin, Matheeussen, A, Besson, Dominique, Fouad Yousif, Gokool Suzanne, Louis Maes, Van Voorhis, Wesley C, Townson, S, Fakorede, F, Yousif, Fouad, Cho-Ngwa, F, Nwaka, Solomon, Maes Louis, Townson Simon, Nwaka Solomon, Wesley C Van Voorhis, Misra-Bhattacharya, Shailja, Ridley Robert, Cho-Ngwa, Fidelis, Robert Ridley, Matheeussen An, Fakorede Foluke, Besson Dominique, Mansour, NR, Matheeussen, An, Paris, JM, Foluke Fakorede, Nuha R Mansour, Mansour, Nuha R, Yeates, C, Gokool, S, Misra-Bhattacharya Shailja, et al.   +79 more
core   +2 more sources

Influence of Testosterone in Neglected Tropical Diseases: Clinical Aspects in Leprosy and In Vitro Experiments in Leishmaniasis

, 2023
Neglected tropical diseases encompass a group of chronic and debilitating infectious diseases that primarily affect marginalized populations. Among these diseases, leprosy and leishmaniasis are endemic in numerous countries and can result in severe and ...
Lucas Sousa Magalhães, Martha Débora Lira Tenório, Daniela Teles de Oliveira, Jonnia Maria Sherlock Araujo, Priscila Lima dos Santos, Laís Lima de Oliveira Rekowsky, Márcio Bezerra-Santos, Ricardo Luís Louzada da Silva, Michael W. Lipscomb, Tiziane Cotta Machado, Rodrigo Anselmo Cazzaniga, Lenise Franco Albuquerque, Amelia Ribeiro de Jesus   +12 more
core   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Somalia: A Nation at the Crossroads of Extreme Poverty, Conflict, and Neglected Tropical Diseases [PDF]

, 2016
The article analyzes the spread of neglected tropical diseases in Somolia due to severe poverty, and civil strife, and discusses the need for reforms to the country’s health systems and infrastructure.
Hotez, Peter J., Jaffer, Annum
core   +1 more source

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

The EU Deforestation Regulation: Challenges, Opportunities and the Potential Impacts on the Producing Countries of Cocoa and Coffee

Environmental Policy and Governance, EarlyView.
ABSTRACT The European Union Deforestation Regulation (EUDR) is a policy that prohibits access to the EU market for commodities that are linked to deforestation. We did a systematic review to understand perceived challenges, opportunities and potential impacts of the EUDR on producing countries of cocoa and coffee.
Alexi Van Loco, Marco Campera
wiley   +1 more source

Can a regulatory instrument promote research and development into neglected diseases? A Policy Delphi Survey [PDF]

, 2012
Fehr A. Can a regulatory instrument promote research and development into neglected diseases? A Policy Delphi Survey. Bielefeld: University of Bielefeld; 2012.Background Rare diseases and neglected diseases are characterized by deficits in drug research ...
Fehr, Angela
core  

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Correction: Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol. [PDF]

PLoS Neglected Tropical Diseases, 2018
[This corrects the article DOI: 10.1371/journal.pntd.0006166.].
PLOS Neglected Tropical Diseases Staff
doaj   +1 more source

Ten global "hotspots" for the neglected tropical diseases. [PDF]

, 2014
In this article, Peter Hotez, fellow in disease and poverty, summarizes 10 of the worst global ﾓhotspotsﾔ where neglected tropical diseases ...
Hotez, Peter J., Peter J Hotez
core   +1 more source